Evidence map›Paper›PMID 30154464›Full record

ArticleNature communications2018

Lysine benzoylation is a histone mark regulated by SIRT2.

He Huang, Di Zhang, Yi Wang, Mathew Perez-Neut, Zhen Han, Y George Zheng, Quan Hao, Yingming Zhao

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 1 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 1 synthesis or guideline pooled it, 209 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Aspirin-Derived Salicyl-CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Biochemistry and regulation of histone lysine L-lactylation.Nature reviews. Molecular cell biology · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

He HuangBen May Department for Cancer Research, The University of Chicago, Chicago, IL, 60637, USA.
Di ZhangBen May Department for Cancer Research, The University of Chicago, Chicago, IL, 60637, USA.
Yi WangSchool of Biomedical Sciences, University of Hong Kong, Hong Kong, China.
Mathew Perez-NeutBen May Department for Cancer Research, The University of Chicago, Chicago, IL, 60637, USA.
Zhen HanDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, 30602, USA.
Y George ZhengDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA, 30602, USA.
Quan HaoSchool of Biomedical Sciences, University of Hong Kong, Hong Kong, China.
Yingming ZhaoBen May Department for Cancer Research, The University of Chicago, Chicago, IL, 60637, USA. Yingming.Zhao@uchicago.edu.
University of Chicago · USUniversity of Georgia · USUniversity of Hong Kong · HK

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
University of Chicago Initiative for Maximizing Student Development (IMSD) - Renewal 01R25GM109439 · NIGMS · UNIVERSITY OF CHICAGO · PI SCHWARTZ, NANCY B · 2014 to 2023
$5.7M
Systematic screening for new histone marks and studying their epigenetic functionR01GM135504 · NIGMS · UNIVERSITY OF CHICAGO · PI ZHAO, YINGMING · 2020 to 2023
$2.1M
SIRT6 and lysine fatty acylation in macrophage inflammationR01DK107868 · NIDDK · CORNELL UNIVERSITY · PI LIN, HENING, ZHAO, YINGMING · 2016 to 2019
$2.0M
Systems-wide analysis of histone lysine 2-hydroxyisobutyrylation pathwayR01GM115961 · NIGMS · UNIVERSITY OF CHICAGO · PI ZHAO, YINGMING · 2016 to 2019
$1.8M
NCATS NIH HHS UL1 TR000430NIDDK NIH HHS R01 DK107868NIGMS NIH HHS R01 GM115961NIGMS NIH HHS R01 GM135504NIGMS NIH HHS R25 GM109439U.S. Department of Health & Human Services | National Institutes of Health (NIH) DK107868U.S. Department of Health & Human Services | National Institutes of Health (NIH) GM115961
6 · The paper itself

Abstract

Metabolic regulation of histone marks is associated with diverse biological processes through dynamically modulating chromatin structure and functions. Here we report the identification and characterization of a histone mark, lysine benzoylation (K

Indexed as

Acyl Coenzyme AAnimalsDrosophila melanogasterEpigenesis, GeneticFood PreservativesGene Expression RegulationGene Knockout TechniquesHEK293 CellsHep G2 CellsHistone CodeHistonesHumansLysineMicePromoter Regions, GeneticRAW 264.7 CellsAcyl Coenzyme Abenzoyl-coenzyme AFood PreservativesHistonesLysineSIRT2 protein, humanSirt2 protein, mouseSirtuin 2Sodium Benzoate

Identifiers

PMID30154464
PMCPMC6113264
OpenAlexW2886279431

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.