Evidence map›Paper›PMID 30154448›Full record

ArticleCell death and differentiation2019

Biochemical re-programming of human dermal stem cells to neurons by increasing mitochondrial membrane potential.

He Liu, Zhaoyue He, Simon Leonhard April, Marcel Philipp Trefny, Jean-Sébastien Rougier, Souzan Salemi, Radu Olariu, Hans Rudolf Widmer, Hans-Uwe Simon

Open access · bronzeAbstract read
In one paragraph

Article in Cell death and differentiation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

He LiuInstitute of Pharmacology, University of Bern, Inselspital, INO-F, CH-3010, Bern, Switzerland.
Zhaoyue HeInstitute of Pharmacology, University of Bern, Inselspital, INO-F, CH-3010, Bern, Switzerland.
Simon Leonhard April *Institute of Pharmacology, University of Bern, Inselspital, INO-F, CH-3010, Bern, Switzerland.
Marcel Philipp Trefny *Institute of Pharmacology, University of Bern, Inselspital, INO-F, CH-3010, Bern, Switzerland.ORCID http://orcid.org/0000-0001-6755-7899
Jean-Sébastien RougierInstitute of Biochemistry and Molecular Medicine, University of Bern, CH-3008, Bern, Switzerland.
Souzan SalemiInstitute of Pharmacology, University of Bern, Inselspital, INO-F, CH-3010, Bern, Switzerland.
Radu OlariuUniversity Hospital for Plastic and Hand Surgery, Bern University Hospital, Inselspital, CH-3010, Bern, Switzerland.
Hans Rudolf WidmerDepartment of Neurosurgery, Research Unit, University of Bern, Inselspital, CH-3010, Bern, Switzerland.
Hans-Uwe SimonInstitute of Pharmacology, University of Bern, Inselspital, INO-F, CH-3010, Bern, Switzerland. hus@pki.unibe.ch.ORCID http://orcid.org/0000-0002-9404-7736
University of Bern · CHUniversity Hospital of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cells are generally believed to contain a small number of mitochondria, thus accounting for their glycolytic phenotype. We demonstrate here, however, that despite an indispensable glucose dependency, human dermal stem cells (hDSCs) contain very numerous mitochondria. Interestingly, these stem cells segregate into two distinct subpopulations. One exhibits high, the other low-mitochondrial membrane potentials (

Indexed as

Membrane Potential, MitochondrialAdultAgedAged, 80 and overCell DifferentiationCells, CulturedDermisFemaleHumansMaleMiddle AgedMitochondriaNeuronsPhosphatidylinositol 3-KinasesReactive Oxygen SpeciesStem CellsPhosphatidylinositol 3-KinasesReactive Oxygen Species

Identifiers

PMID30154448
PMCPMC6748123
OpenAlexW2889453614

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.