ArticleCell death and differentiation2019
Characterisation of mice lacking the inflammatory caspases-1/11/12 reveals no contribution of caspase-12 to cell death and sepsis.
Article in Cell death and differentiation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Innate immune sensing of Plasmodium sporozoite cell traversal drives protective T cell responses.Nature microbiology · 2026Article
- Caspase Domain Duplication During the Evolution of Caspase-16.Journal of molecular evolution · 2025Article
- Caspases: structural and molecular mechanisms and functions in cell death, innate immunity, and disease.Cell discovery · 2025Review
- Caspase-12 is Expressed in Purkinje Neurons and Prevents Psychiatric-Like Behavior in Mice.Molecular neurobiology · 2025Article
- Comprehensive Analysis of Multi-Omics Data on RNA Polymerase as an Adverse Factor in Head and Neck Squamous Cell Carcinoma.Journal of inflammation research · 2025Article
- Exploring caspase functions in mouse models.Apoptosis : an international journal on programmed cell death · 2024Review
- Optimal strategy for treatment of sepsis based on the host inflammatory reaction and immune response.Journal of intensive medicine · 2024Article
- Immunoadjuvant therapy in the regulation of cell death in sepsis: recent advances and future directions.Frontiers in immunology · 2024Review
- Article
- Caspases help to spread the message via extracellular vesicles.The FEBS journal · 2023Review
- Deletion of Gpatch2 does not alter Tnf expression in mice.Cell death & disease · 2023Article
- PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options.Military Medical Research · 2022Review
- Identification of immune-related endoplasmic reticulum stress genes in sepsis using bioinformatics and machine learning.Frontiers in immunology · 2022Article
- Focus on the Mechanisms and Functions of Pyroptosis, Inflammasomes, and Inflammatory Caspases in Infectious Diseases.Oxidative medicine and cellular longevity · 2022Review
- The "Self-Sacrifice" of ImmuneCells in Sepsis.Frontiers in immunology · 2022Review
- Reciprocal regulation between ER stress and autophagy in renal tubular fibrosis and apoptosis.Cell death & disease · 2021Article
- Silencing of FTX suppresses pancreatic cancer cell proliferation and invasion by upregulating miR-513b-5p.BMC cancer · 2021Article
- Emerging connectivity of programmed cell death pathways and its physiological implications.Nature reviews. Molecular cell biology · 2020Review
- Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection.Immunity · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caspases exert critical functions in diverse cell death pathways, including apoptosis and pyroptosis, but some caspases also have roles in the processing of cytokines into their functional forms during inflammation. The roles of many caspases have been unravelled by the generation of knockout mice, but still very little is known about the overlapping functions of caspases as only a few studies report on double or triple caspase knockout mice. For example, the functions of caspase-12 in cell death and inflammation, on its own or overlapping with the functions of caspase-1 and caspase-11, are only poorly understood. Therefore, we generated a novel mutant mouse strain lacking all three inflammatory caspases, caspases-1, -11 and -12. Analysis under steady state conditions showed no obvious differences between caspase-1/11/12
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.