ArticleNature communications2018
March1-dependent modulation of donor MHC II on CD103
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- The DC1 conundrum: Do type I dendritic cells make or break allograft tolerance?American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Review
- RETREG1-Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Optineurin modulates mTORC2/AKT/STAT3 signaling to control MHC class II expression and adaptive immunity against HSV-1.Cell reports · 2026Article
- Best practices in mouse models of skin transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Review
- Macrophage migration inhibitory factor of zoonoticiScience · 2026Article
- MARCH1, transcriptionally regulated by POU2F2, facilitates acute myeloid leukemia progression via inducing MYCT1 degradation.Oncogene · 2025Article
- Human type 1 conventional dendritic cells contribute to skin transplant rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Article
- Dual roles of innate immune cells and cytokines in shaping the breast cancer microenvironment.Frontiers in immunology · 2025Review
- Role of MARCH E3 ubiquitin ligases in cancer development.Cancer metastasis reviews · 2024Review
- Molecular Chaperone Receptors: An Update.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses.Nature communications · 2022Article
- T cell-attracting CCL18 chemokine is a dominant rejection signal during limb transplantation.Cell reports. Medicine · 2022Article
- Antigen transfer and its effect on vaccine-induced immune amplification and tolerance.Theranostics · 2022Review
- The functions and regulation of heat shock proteins; key orchestrators of proteostasis and the heat shock response.Archives of toxicology · 2021Review
- Ubiquitination of MHC Class II by March-I Regulates Dendritic Cell Fitness.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Targeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways.Signal transduction and targeted therapy · 2021Review
- Host expression system modulates recombinant Hsp70 activity through post-translational modifications.The FEBS journal · 2020Article
- Roles of Ubiquitination and Deubiquitination in Regulating Dendritic Cell Maturation and Function.Frontiers in immunology · 2020Review
- Complete loss of the MHC II pathway in an anglerfish,Biology letters · 2019Article
- Preformed Donor-specific Antibodies Against HLA Class II and Graft Outcomes in Deceased-donor Kidney Transplantation.Transplantation direct · 2019Article
Corrections and comments
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Authors and funding
22 authors at 8 institutions in 3 countries.
Thiago J BorgesSchool of Biosciences and Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS. Av. Ipiranga, 6690, IPB, 2nd floor, lab 6, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-6554-0169
Naoka MurakamiSchuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA, 02115, USA.
Felipe D MachadoSchool of Biosciences and Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS. Av. Ipiranga, 6690, IPB, 2nd floor, lab 6, Porto Alegre, RS, Brazil.
Ayesha MurshidDepartment of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.
Benjamin J LangDepartment of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0002-2205-8591
Rafael L LopesSchool of Biosciences and Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS. Av. Ipiranga, 6690, IPB, 2nd floor, lab 6, Porto Alegre, RS, Brazil.
Laura M BellanSchool of Biosciences and Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS. Av. Ipiranga, 6690, IPB, 2nd floor, lab 6, Porto Alegre, RS, Brazil.ORCID http://orcid.org/0000-0002-0595-2890
Mayuko UeharaSchuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA, 02115, USA.
Krist H AntunesSchool of Pharmacy and Centro Infant, Biomedical Research Institute, PUCRS. Av. Ipiranga, 6690, IPB, 2nd floor, lab 31, Porto Alegre, RS, Brazil.
Maria José Pérez-SaézSchuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA, 02115, USA.
Gabriel BirraneDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0002-1759-5499
Priscila ViannaGenetics Department, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, 9500, Porto Alegre, RS, Brazil.
João Ismael B GonçalvesSchool of Biosciences and Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS. Av. Ipiranga, 6690, IPB, 2nd floor, lab 6, Porto Alegre, RS, Brazil.
Rafael F ZaninSchool of Biosciences and Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS. Av. Ipiranga, 6690, IPB, 2nd floor, lab 6, Porto Alegre, RS, Brazil.
Jamil AzziSchuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA, 02115, USA.
Reza AbdiSchuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA, 02115, USA.
Satoshi IshidoDepartment of Microbiology, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan.
Jeoung-Sook ShinDepartment of Microbiology and Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, 513 Parnassus Ave, HSE-201, San Francisco, CA, 94143-0414, USA.
Ana Paula D SouzaDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Ave, Boston, MA, 02215, USA.
Stuart K CalderwoodDepartment of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0001-9966-3354
Leonardo V RiellaSchuster Family Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA, 02115, USA. lriella@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-7636-3196
Cristina BonorinoSchool of Biosciences and Biomedical Research Institute, Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS. Av. Ipiranga, 6690, IPB, 2nd floor, lab 6, Porto Alegre, RS, Brazil. cristinabonorino@gmail.com.ORCID http://orcid.org/0000-0003-2755-3978
Brigham and Women's Hospital · USBeth Israel Deaconess Medical Center · USPontifícia Universidade Católica do Rio Grande do Sul · BRUniversidade La Salle · BRHyogo Medical University · JPUniversidade Federal de Ciências da Saúde de Porto Alegre · BRUniversidade Federal do Rio Grande do Sul · BRUniversity of California, San Francisco · US
Funding
The Next Generation Immunoanalysis CoreP30AR069625 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CLARK, RACHAEL ANN · 2016 to 2025
$8.8MTRAINING PROGRAM IN ACADEMIC NEPHROLOGYT32DK007527 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 1986 to 2021
$8.8MExtracellular Hsp70 and hyperthermia in tumor therapyR01CA119045 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CALDERWOOD, STUART KEITH · 2007 to 2016
$3.1MProtection of organ transplant from ischemia reperfusion injuriesR01AI126596 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ABDI, REZA · 2016 to 2020
$2.6MRole of MARCH1 E3 ubiquitin ligase in thymic dendritic cell functionR01GM105800 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHIN, JEOUNG-SOOK · 2013 to 2017
$1.5MAmerican Heart Association (American Heart Association, Inc.) 12FTF120070328Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (Research Support Foundation of the State of Rio Grande do Sul) 11/0903-1Ministry of Science, Technology and Innovation | Financiadora de Estudos e Projetos (Funding Authority for Research and Projects) 01.08.0600-00NCI NIH HHS R01 CA119045NIAID NIH HHS R01 AI126596NIAMS NIH HHS P30 AR069625NIDDK NIH HHS T32 DK007527NIGMS NIH HHS R01 GM105800U.S. Department of Defense (DOD) RT150078 and RT150081
Abstract
In transplantation, donor dendritic cells (do-DCs) initiate the alloimmune response either by direct interaction with host T cells or by transferring intact donor MHC to host DCs. However, how do-DCs can be targeted for improving allograft survival is still unclear. Here we show CD103
Indexed as
AnimalsAntigens, CDBasic-Leucine Zipper Transcription FactorsDendritic CellsHistocompatibility Antigens Class IIIntegrin alpha ChainsInterleukin-10MiceMice, Inbred BALB CMice, Inbred C57BLRepressor ProteinsSTAT3 Transcription FactorUbiquitin-Protein Ligasesalpha E integrinsAntigens, CDBasic-Leucine Zipper Transcription FactorsHistocompatibility Antigens Class IIIntegrin alpha ChainsInterleukin-10MARCH1 protein, mouseRepressor ProteinsSNFT protein, mouseSTAT3 Transcription FactorUbiquitin-Protein Ligases
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