Evidence map›Paper›PMID 30154342›Full record

ArticleInternational journal of molecular sciences2018

Diagnostic and Prognostic Implications of FGFR3

Mirja Geelvink, Armin Babmorad, Angela Maurer, Robert Stöhr, Tobias Grimm, Christian Bach, Ruth Knuechel, Michael Rose, Nadine T Gaisa

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Magnetic resonance imaging-based radiomics signature for preoperative prediction of Ki67 expression in bladder cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2021
    Article
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mirja GeelvinkInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany. mirja.geelvink@rwth-aachen.de.
Armin BabmoradInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany. armin.babmorad@rwth-aachen.de.
Angela MaurerInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany. amaurer@ukaachen.de.
Robert StöhrInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany. Robert.Stoehr@uk-erlangen.de.
Tobias GrimmDepartment of Urology, Ludwig Maximilian University Munich, 81377 Munich, Germany. Tobias_Grimm@med.uni-muenchen.de.ORCID 0000-0002-6782-6638
Christian BachDepartment of Urology, RWTH Aachen University, 52074 Aachen, Germany. chbach@ukaachen.de.
Ruth KnuechelInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany. rknuechel-clarke@ukaachen.de.
Michael RoseInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany. mrose@ukaachen.de.
Nadine T GaisaInstitute of Pathology, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany. ngaisa@ukaachen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prognostic/therapeutic stratification of papillary urothelial cancers is solely based upon histology, despite activated FGFR3-signaling was found to be associated with low grade tumors and favorable outcome. However, there are FGFR3-overexpressing tumors showing high proliferation-a paradox of coexisting favorable and adverse features. Therefore, our study aimed to decipher the relevance of FGFR3-overexpression/proliferation for histopathological grading and risk stratification.

Indexed as

AgedAged, 80 and overBiomarkers, TumorCarcinoma, PapillaryFemaleHumansImmunohistochemistryKi-67 AntigenMaleMiddle AgedMutationNeoplasm GradingNeoplasm StagingPrognosisProportional Hazards ModelsReceptor, Fibroblast Growth Factor, Type 3Biomarkers, TumorFGFR3 protein, humanKi-67 AntigenMKI67 protein, humanReceptor, Fibroblast Growth Factor, Type 3Tumor Suppressor Protein p53bladder cancerFGFR3Ki67prognosisTP53

Identifiers

PMID30154342
PMCPMC6163244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.