Evidence map›Paper›PMID 30154264›Full record

ArticlemBio2018

The Metabolic Redox Regime of Pseudomonas putida Tunes Its Evolvability toward Novel Xenobiotic Substrates.

Özlem Akkaya, Danilo R Pérez-Pantoja, Belén Calles, Pablo I Nikel, Víctor de Lorenzo

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
6.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Özlem AkkayaDepartment of Molecular Biology and Genetics, Faculty of Sciences, Gebze Technical University, Kocaeli, Turkey.
Danilo R Pérez-PantojaPrograma Institucional de Fomento a la Investigación, Desarrollo e Innovación, Universidad Tecnológica Metropolitana, Santiago de Chile, Chile.
Belén CallesSystems and Synthetic Biology Program, Centro Nacional de Biotecnología, Madrid, Spain.
Pablo I NikelNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark pabnik@biosustain.dtu.dk vdlorenzo@cnb.csic.es.ORCID 0000-0002-9313-7481
Víctor de LorenzoSystems and Synthetic Biology Program, Centro Nacional de Biotecnología, Madrid, Spain pabnik@biosustain.dtu.dk vdlorenzo@cnb.csic.es.ORCID 0000-0002-6041-2731
Centro Nacional de Biotecnología · ESGebze Technical University · TRMetropolitan University of Technology · CLNovo Nordisk Foundation · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During evolution of biodegradation pathways for xenobiotic compounds involving Rieske nonheme iron oxygenases, the transition toward novel substrates is frequently associated with faulty reactions. Such events release reactive oxygen species (ROS), which are endowed with high mutagenic potential. In this study, we evaluated how the operation of the background metabolic network by an environmental bacterium may either foster or curtail the still-evolving pathway for 2,4-dinitrotoluene (2,4-DNT) catabolism. To this end, the genetically tractable strain

Indexed as

Bacterial ProteinsBiodegradation, EnvironmentalBurkholderiaDinitrobenzenesEvolution, MolecularMetabolic Networks and PathwaysMutagenesisNADPH OxidasesOxidation-ReductionOxidative StressPseudomonas putidaReactive Oxygen SpeciesXenobiotics2,4-dinitrotolueneBacterial ProteinsDinitrobenzenesNADPH OxidasesReactive Oxygen SpeciesXenobioticsbiodegradationdinitrotolueneevolutionNADPH oxidasesoxidative stressPseudomonas putidareactive oxygen species

Identifiers

PMID30154264
PMCPMC6113623
OpenAlexW2981505157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.