Evidence map›Paper›PMID 30154263›Full record

ArticlemBio2018

NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of Toxoplasma gondii in Naive Macrophages.

Sumit K Matta, Kelley Patten, Quiling Wang, Bae-Hoon Kim, John D MacMicking, L David Sibley

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Frontiers in immunology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Susceptibility ofmBio · 2024
    Article
  14. Metabolic changes to host cells withbioRxiv : the preprint server for biology · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sumit K MattaDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Kelley PattenDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Quiling WangDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Bae-Hoon KimHoward Hughes Medical Institute, West Haven, Connecticut, USA.
John D MacMickingHoward Hughes Medical Institute, West Haven, Connecticut, USA.
L David SibleyDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA sibley@borcim.wustl.edu.
Washington University in St. Louis · USHoward Hughes Medical Institute · USYale University · US

Funding

Molecular Basis of Human ToxoplasmosisR01AI118426 · NIAID · WASHINGTON UNIVERSITY · PI SIBLEY, L. DAVID · 2015 to 2024
$6.0M
Immune control of tuberculosis by IFN-gamma-inducible LRG-47R01AI068041 · NIAID · YALE UNIVERSITY · PI MACMICKING, JOHN DAVID · 2006 to 2021
$5.9M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI068041NIAID NIH HHS R01 AI118426
6 · The paper itself

Abstract

Phagocytic cells are the first line of innate defense against intracellular pathogens, and yet

Indexed as

AnimalsCells, CulturedGTP-Binding ProteinsImmunity, InnateInterferonsMacrophagesMiceMice, Inbred C57BLMice, KnockoutNADPH Oxidase 1NADPH Oxidase 2RAW 264.7 CellsReactive Oxygen SpeciesToxoplasmaToxoplasmosisVirulenceCybb protein, mouseGbp5 protein, mouseGTP-Binding ProteinsInterferonsNADPH Oxidase 1NADPH Oxidase 2NOX1 protein, mouseReactive Oxygen Speciesautophagychronic granulomatous diseaseinnate immunityinterferonsintracellular parasitesmembrane damagereactive oxygen speciestoxoplasmosis

Identifiers

PMID30154263
PMCPMC6113620
OpenAlexW2889504847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.