Evidence map›Paper›PMID 30154242›Full record

ArticleThe Journal of biological chemistry2018

Deletion of mitochondrial calcium uniporter incompletely inhibits calcium uptake and induction of the permeability transition pore in brain mitochondria.

James Hamilton, Tatiana Brustovetsky, Jacob E Rysted, Zhihong Lin, Yuriy M Usachev, Nickolay Brustovetsky

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
  2. Article
  3. The two faces of mitochondrial CaJournal of physiology and biochemistry · 2026
    Review
  4. Article
  5. Article
  6. Mitochondrial CaBiomolecules · 2026
    Review
  7. Article
  8. Article
  9. MICU proteins facilitate CaResearch square · 2025
    Article
  10. Mitochondrial CaCell calcium · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Enhanced mitochondrial buffering prevents CaThe Journal of physiology · 2024
    Article
  17. Article
  18. MCU-independent CaScientific reports · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

James HamiltonFrom the Department of Pharmacology and Toxicology and.
Tatiana BrustovetskyFrom the Department of Pharmacology and Toxicology and.
Jacob E Rystedthe Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242.
Zhihong Linthe Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242.
Yuriy M Usachevthe Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242.
Nickolay BrustovetskyFrom the Department of Pharmacology and Toxicology and nbrous@iu.edu.ORCID 0000-0002-6564-2560
University of Iowa · USIndiana University School of MedicineIndiana University – Purdue University Indianapolis · US

Funding

CRMP2, mitochondria, and Huntington’s diseaseR01NS098772 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI BRUSTOVETSKY, NICKOLAY, KHANNA, RAJESH · 2017 to 2021
$2.8M
Molecular Mechanisms and Functions of Mitochondrial Ca2+ transport in NeuronsR01NS096246 · NINDS · UNIVERSITY OF IOWA · PI USACHEV, YURIY M · 2016 to 2020
$2.2M
Mitochondria fission and fusion (MFF)-dependent mechanisms in neuronal toxicityR01NS087068 · NINDS · UNIVERSITY OF IOWA · PI USACHEV, YURIY M · 2014 to 2017
$1.3M
NINDS NIH HHS R01 NS087068NINDS NIH HHS R01 NS096246NINDS NIH HHS R01 NS098772
6 · The paper itself

Abstract

Ca

Indexed as

AnimalsBrainCalciumCalcium ChannelsCyclohexanesDantroleneFemaleGene DeletionIonophoresIon TransportMalatesMaleMiceMice, KnockoutMitochondriaMitochondria, Heart7-chloro-5-(2-isopropylphenyl)-3,5-dihydro-4,1-benzothiazepin-2-(1H)-oneCalciumCalcium ChannelsCyclohexanesDantroleneIonophoresMalatesmalic acidmitochondrial calcium uniporterMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreN,N,N',N'-tetracyclohexyl-3-oxapentanediamidePyruvic AcidRu 360Ruthenium CompoundsThiazepinescalciumcyclophilin Denergy metabolismion channelmitochondriamitochondrial membrane potentialmitochondrial permeability transition (MPT)respiration

Identifiers

PMID30154242
PMCPMC6177608
OpenAlexW2888917034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.