Evidence map›Paper›PMID 30154188›Full record

ArticleThe Journal of cell biology2018

Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration.

Laura E Newman, Gerald S Shadel

Open access · bronzeAbstract readComment
In one paragraph

Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
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  6. Cell-Free DNA and Mitochondria in Parkinson's Disease.International journal of molecular sciences · 2025
    Review
  7. Article
  8. MicroRNAs and synaptic dysfunction in Parkinson's disease.Molecular therapy. Nucleic acids · 2025
    Review
  9. Article
  10. Review
  11. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Laura E NewmanThe Salk Institute for Biological Studies, La Jolla, CA.
Gerald S ShadelThe Salk Institute for Biological Studies, La Jolla, CA gshadel@salk.edu.ORCID 0000-0003-2899-8717
Salk Institute for Biological Studies · US

Funding

Mitochondrial DNA Stress Activation of Interferon Signaling and Lupus PathologyR01AR069876 · NIAMS · YALE UNIVERSITY · PI SHADEL, GERALD · 2017 to 2021
$2.1M
Inducible Mouse Models of Mitochondrial ROS Signaling and Environment StressR33ES025636 · NIEHS · YALE UNIVERSITY · PI SHADEL, GERALD · 2017 to 2019
$1.7M
NIAMS NIH HHS R01 AR069876NIEHS NIH HHS R33 ES025636
6 · The paper itself

Abstract

What causes inflammation in age-related neurodegenerative diseases remains a mystery. Sliter et al. (2018.

Indexed as

MitophagyProtein KinasesHumansInflammationMitochondriaUbiquitin-Protein LigasesProtein KinasesUbiquitin-Protein Ligases

Identifiers

PMID30154188
PMCPMC6168260
OpenAlexW2889452210

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.