ArticleProceedings of the National Academy of Sciences of the United States of America2018
Changes in membrane properties of rat deep cerebellar nuclear projection neurons during acquisition of eyeblink conditioning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 24 citations in OpenAlex.
- Temporal dynamics of Purkinje cell-intrinsic excitability governs cerebellar systems consolidation.iScience · 2025Article
- Cerebellum Lecture: the Cerebellar Nuclei-Core of the Cerebellum.Cerebellum (London, England) · 2024Review
- The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning.Biology · 2024Review
- Synaptic mechanisms for associative learning in the cerebellar nuclei.Nature communications · 2023Article
- Eyeblink tract tracing with two strains of herpes simplex virus 1.Brain research · 2022Article
- Heterogeneity of intrinsic plasticity in cerebellar Purkinje cells linked with cortical molecular zones.iScience · 2022Article
- Functional properties of eyelid conditioned responses and involved brain centers.Frontiers in behavioral neuroscience · 2022Review
- Brain-inspired classical conditioning model.iScience · 2021Article
- Disruption of rat deep cerebellar perineuronal net alters eyeblink conditioning and neuronal electrophysiology.Neurobiology of learning and memory · 2021Article
- Circuits for State-Dependent Modulation of Locomotion.Frontiers in human neuroscience · 2021Review
- Modification of Synaptic-Input Clustering by Intrinsic Excitability Plasticity on Cerebellar Purkinje Cell Dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces.PLoS biology · 2020Article
- Learning and aging affect neuronal excitability and learning.Neurobiology of learning and memory · 2020Review
- Changes in cerebellar intrinsic neuronal excitability and synaptic plasticity result from eyeblink conditioning.Neurobiology of learning and memory · 2019Review
- Tumor Necrosis Factor-Alpha Alters Electrophysiological Properties of Rabbit Hippocampal Neurons.Journal of Alzheimer's disease : JAD · 2019Article
- Long-Lasting Response Changes in Deep Cerebellar NucleiFrontiers in cellular neuroscience · 2019Article
- Intrinsic excitement in cerebellar nuclei neurons during learning.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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6 authors at 2 institutions in 1 country.
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Abstract
Previous studies have shown changes in membrane properties of neurons in rat deep cerebellar nuclei (DCN) as a function of development, but due to technical difficulties in obtaining viable DCN slices from adult animals, it remains unclear whether there are learning-related alterations in the membrane properties of DCN neurons in adult rats. This study was designed to record from identified DCN cells in cerebellar slices from postnatal day 25-26 (P25-26) rats that had a relatively mature sensory nervous system and were able to acquire learning as a result of tone-shock eyeblink conditioning (EBC) and to document resulting changes in electrophysiological properties. After electromyographic electrode implantation at P21 and inoculation with a fluorescent pseudorabies virus (PRV-152) at P22-23, rats received either four sessions of paired delay EBC or unpaired stimulus presentations with a tone conditioned stimulus and a shock unconditioned stimulus or sat in the training chamber without stimulus presentations. Compared with rats given unpaired stimuli or no stimulus presentations, rats given paired EBC showed an increase in conditioned responses across sessions. Whole-cell recordings of both fluorescent and nonfluorescent DCN projection neurons showed that delay EBC induced significant changes in membrane properties of evoked DCN action potentials including a reduced after-hyperpolarization amplitude and shortened latency. Similar findings were obtained in hyperpolarization-induced rebound spikes of DCN neurons. In sum, delay EBC produced significant changes in the membrane properties of juvenile rat DCN projection neurons. These learning-specific changes in DCN excitability have not previously been reported in any species or task.
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