ArticleBlood2018
SCID genotype and 6-month posttransplant CD4 count predict survival and immune recovery.
Registry-linked trialOpen access · bronzeAbstract read
In one paragraph
Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01346150 (A Retrospective and Cross-Sectional Analysis of Patients Treated for SCID Since January 1,1968), which is not on this map. Cited by 109 papers.
0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Retrospective and Cross-Sectional Analysis of Patients Treated for SCID Since January 1,1968 (RDCRN PIDTC-6902)
Who cites it
109 citing papers in PubMed, 169 citations in OpenAlex.
- Lentiviral Gene Therapy for Artemis-Deficient SCID.The New England journal of medicine · 2022Trial
- Outcomes following treatment for ADA-deficient severe combined immunodeficiency: a report from the PIDTC.Blood · 2022Trial
- Low Exposure Busulfan Conditioning to Achieve Sufficient Multilineage Chimerism in Patients with Severe Combined Immunodeficiency.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019Trial
- Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.The New England journal of medicine · 2019Trial
- The genetic landscape of severe combined immunodeficiency in the United States and Canada in the current era (2010-2018).The Journal of allergy and clinical immunology · 2019Trial
- Clinical, immunological, and molecular characteristics of severe combined immune deficiency in China.Human genetics · 2026Article
- Newborn screening reduces survival disparities in SCID after stem cell transplant: A PIDTC report.Journal of human immunity · 2026Article
- Excellent survival after allogeneic HSCT in screened SCID patients and donor type dependent naïve T cell reconstitution.Bone marrow transplantation · 2026Article
- Updated EBMT/ESID inborn errors working party guidelines for haematopoietic stem cell transplantation for inborn errors of immunity and metabolism.Bone marrow transplantation · 2026Review
- Bringing the rare into sight: applications of haploidentical stem cell transplantation in the treatment of rare diseases.Bone marrow transplantation · 2026Review
- Base editing of Artemis mutations ex vivo sheds light on gene therapy for Artemis-deficient SCID.Advanced biotechnology · 2026Article
- Novel molecular assays for monitoring T cell function after HSCT in two siblings with variants inJournal of human immunity · 2026Article
- Treosulfan-fludarabine conditioning in infants with severe combined immunodeficiencies: Extended study of the UK paediatric treosulfan study.British journal of haematology · 2026Article
- Outcomes following matched sibling donor transplantation for severe combined immunodeficiency: a report from the PIDTC.Blood advances · 2026Article
- Neurodevelopmental outcomes following hematopoietic cell transplantation for patients with severe combined immunodeficiency (SCID): A PIDTC study.Journal of human immunity · 2026Article
- IL2RG-related immunodeficiencies: from SCID to atypical presentations.Frontiers in immunology · 2026Review
- Double-hit RAG2 mutation presenting with hyper-immunoglobulin E and preserved T cells diagnostic challenge: a case report.Journal of medical case reports · 2025Article
- HoxBlinc lncRNA reprograms CTCF-independent TADs to drive leukemic transcription and HSC dysregulation in NUP98-rearranged leukemia.The Journal of clinical investigation · 2025Article
- Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature.Science immunology · 2025Article
- JAK/STAT in human diseases: a common axis in immunodeficiencies and hematological disorders.Frontiers in immunology · 2025Review
49 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
65 authors at 20 institutions in 2 countries.
Elie HaddadPediatric Immunology and Rheumatology Division, CHU Sainte-Justine, University of Montreal, Montreal, QC, Canada.ORCID 0000-0003-2446-6879
Brent R LoganDivision of Biostatistics, Medical College of Wisconsin, Milwaukee, WI.
Linda M GriffithDivision of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Rebecca H BuckleyDuke University Medical Center, Durham, NC.
Roberta E ParrottDuke University Medical Center, Durham, NC.
Susan E ProckopDepartment of Pediatrics, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY.
Trudy N SmallDepartment of Pediatrics, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY.
Jessica ChaissonDepartment of Pediatrics, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY.
Christopher C DvorakPediatric Allergy, Immunology, and Blood and Marrow Transplant Division, University of California, San Francisco Benioff Children's Hospital, San Francisco, CA.
Megan MurnanePediatric Allergy, Immunology, and Blood and Marrow Transplant Division, University of California, San Francisco Benioff Children's Hospital, San Francisco, CA.
Neena KapoorBlood and Marrow Transplant Program, Division of Hematology, Oncology and Blood and Marrow Transplantation, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Hisham Abdel-AzimBlood and Marrow Transplant Program, Division of Hematology, Oncology and Blood and Marrow Transplantation, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Imelda C HansonImmunology, Allergy and Rheumatology and.
Caridad MartinezCenter for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital, Houston, TX.
Jack J H BleesingBone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Sharat ChandraBone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Angela R SmithDivision of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN.
Matthew E CavanaughHematology-Oncology, Boston Children's Hospital, Boston, MA.
Soma JyonouchiAllergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA.
Kathleen E SullivanAllergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA.
Lauri BurroughsFred Hutchinson Cancer Research Center, Seattle, WA.
Suzanne Skoda-SmithSeattle Children's Hospital, Seattle, WA.
Ann E HaightAflac Cancer and Blood Disorders Center, Emory/Children's Healthcare of Atlanta, Atlanta, GA.
Audrey G TumlinAflac Cancer and Blood Disorders Center, Emory/Children's Healthcare of Atlanta, Atlanta, GA.
Troy C QuiggTexas Transplant Institute, Methodist Children's Hospital, San Antonio, TX.
Candace TaylorTexas Transplant Institute, Methodist Children's Hospital, San Antonio, TX.
Blachy J Dávila SaldañaDivision of Blood and Marrow Transplantation, Children's National Health System, George Washington University School of Medicine and Health Sciences, Washington, DC.
Michael D KellerDivision of Blood and Marrow Transplantation, Children's National Health System, George Washington University School of Medicine and Health Sciences, Washington, DC.
Christine M SeroogyAmerican Family Children's Hospital, University of Wisconsin, Madison, WI.
Kenneth B DesantesAmerican Family Children's Hospital, University of Wisconsin, Madison, WI.
Aleksandra PetrovicBlood and Marrow Transplant, John Hopkins All Children's Hospital, St. Petersburg, FL.
Jennifer W LeidingBlood and Marrow Transplant, John Hopkins All Children's Hospital, St. Petersburg, FL.
David C ShyrDepartment of Pediatrics, Primary Children's Hospital, University of Utah, Salt Lake City, UT.
Hélène DecaluwePediatric Immunology and Rheumatology Division, CHU Sainte-Justine, University of Montreal, Montreal, QC, Canada.
Pierre TeiraPediatric Immunology and Rheumatology Division, CHU Sainte-Justine, University of Montreal, Montreal, QC, Canada.
Alfred P GillioInstitute for Pediatric Cancer and Blood Disorders, Hackensack University Medical Center, Hackensack, NJ.
Alan P KnutsenPediatric Allergy and Immunology, Saint Louis University, Cardinal Glennon Children's Medical Center, St. Louis, MO.
Theodore B MoorePediatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA.
Morris KletzelDivision of Hematology, Oncology, and Stem Cell Transplantation, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL.
John A CraddockChildren's Hospital of Colorado, University of Colorado School of Medicine, Aurora, CO.
Victor AquinoPediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Jeffrey H DavisPediatrics, British Columbia Children's Hospital, Vancouver, BC, Canada.
Lolie C YuDivision of Hematology/Oncology and Hematopoietic Stem Cell Transplantation, The Center for Cancer and Blood Disorders, Children's Hospital/Louisiana State University Medical Center, New Orleans, LA.
Geoffrey D E CuvelierManitoba Blood and Marrow Transplant Program, CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Jeffrey J BednarskiPediatrics, Washington University School of Medicine, St. Louis, MO.
Frederick D GoldmanDepartment of Pediatrics, The University of Alabama at Birmingham, Birmingham, AL.
Elizabeth M KangGenetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Evan ShereckDivision of Pediatric Hematology/Oncology, Oregon Health and Science University, Portland, OR.
Matthew H PorteusPediatric Stem Cell Transplantation, Stanford University, Stanford, CA.
James A ConnellyVanderbilt University Medical Center, Nashville, TN.
Thomas A FleisherDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.
Harry L MalechGenetic Immunotherapy Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
William T ShearerImmunology, Allergy and Rheumatology and.
Paul SzabolcsChildren's Hospital of Pittsburgh, Pittsburgh, PA.
Monica S ThakarPediatric Blood and Marrow Transplant Program, Division of Hematology, Oncology, and Blood Marrow Transplantation, Medical College of Wisconsin, Milwaukee, WI.
Mark T Vander LugtPediatric Hematology/Oncology, University of Michigan, Ann Arbor, MI; and.
Jennifer HeimallAllergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA.
Ziyan YinDivision of Biostatistics, Medical College of Wisconsin, Milwaukee, WI.
Michael A PulsipherBlood and Marrow Transplant Program, Division of Hematology, Oncology and Blood and Marrow Transplantation, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Sung-Yun PaiHematology-Oncology, Boston Children's Hospital, Boston, MA.
Donald B KohnPediatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA.
Jennifer M PuckPediatric Allergy, Immunology, and Blood and Marrow Transplant Division, University of California, San Francisco Benioff Children's Hospital, San Francisco, CA.
Morton J CowanPediatric Allergy, Immunology, and Blood and Marrow Transplant Division, University of California, San Francisco Benioff Children's Hospital, San Francisco, CA.
Richard J O'ReillyDepartment of Pediatrics, Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Memorial Sloan Kettering Cancer Center · USNational Institutes of Health · USUniversity of California, San Francisco · USCentre Hospitalier Universitaire Sainte-Justine · CAChildren's Hospital of Philadelphia · USMedical College of Wisconsin · USUniversity of Southern California · USAflac (United States) · USBoston Children's Hospital · USChildren's National · USCincinnati Children's Hospital Medical Center · USDuke Medical Center · USENT and Allergy · USJohns Hopkins University · USMethodist Children’s Hospital · USSeattle Children's Hospital · USUniversity of California, Los Angeles · USUniversity of Wisconsin–Madison · USBaylor College of Medicine · USBC Children's Hospital · CA
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MData Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2MPB vs. BMU01HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2001 to 2010
$63.3MRare Diseases Data Management and Coordinating CenterU01TR001263 · NCATS · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2014 to 2018
$28.1MTraining of Clinical Investigators in Primary Immune DeficienciesU54AI082973 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PAI, SUNG-YUN · 2009 to 2023
$23.3MData Management and Coordinating Center (DMCC)U54NS064808 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI KRISCHER, JEFFREY P · 2009 to 2013
$16.5MCharacterization of the cellular and molecular bases of inborn errors of immunityZIAAI001222 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NOTARANGELO, LUIGI · 2017 to 2025
$15.2MDevelopment and conduct of allogeneic stem cell transplant and autologous stem cell gene therapy for inherited immune deficienciesZIAAI000989 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KANG, ELIZABETH · 2009 to 2025
$12.4MGene Therapy Basic Research to Treat Inherited Primary Immune DeficienciesZIAAI000644 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MALECH, HARRY L · 2009 to 2025
$12.1MDevelopment and Clinical Application of Gene and Cell therapies for Patients with Immune DeficienciesZIAAI000645 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DE RAVIN, SUK SEE · 2009 to 2025
$10.1MBasic Research on Hematopoietic Human Stem CellsZIAAI000988 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MALECH, HARRY L · 2009 to 2019
$6.5MBlood and Marrow Transplant Clinical Trials NetworkU10HL069254 · NHLBI · UNIVERSITY OF UTAH · PI PULSIPHER, MICHAEL A · 2011 to 2016
$839kNCATS NIH HHS U01 TR001263NCI NIH HHS P30 CA008748NCI NIH HHS U24 CA076518NHLBI NIH HHS U01 HL069294NHLBI NIH HHS U10 HL069254NIAID NIH HHS R13 AI094943NIAID NIH HHS U54 AI082973NINDS NIH HHS U54 NS064808
Abstract
The Primary Immune Deficiency Treatment Consortium (PIDTC) performed a retrospective analysis of 662 patients with severe combined immunodeficiency (SCID) who received a hematopoietic cell transplantation (HCT) as first-line treatment between 1982 and 2012 in 33 North American institutions. Overall survival was higher after HCT from matched-sibling donors (MSDs). Among recipients of non-MSD HCT, multivariate analysis showed that the SCID genotype strongly influenced survival and immune reconstitution. Overall survival was similar for patients with
Indexed as
Hematopoietic Stem Cell TransplantationCD4-Positive T-LymphocytesGenotypeHumansImmune ReconstitutionLymphocyte CountRetrospective StudiesSevere Combined Immunodeficiency
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT01346150ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.