Evidence map›Paper›PMID 30154079›Full record

ArticleDisease models & mechanisms2018

Zoledronic acid prevents pagetic-like lesions and accelerated bone loss in the p62

Anna Daroszewska, Lorraine Rose, Nadine Sarsam, Gemma Charlesworth, Amanda Prior, Kenneth Rose, Stuart H Ralston, Robert J van 't Hof

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease models & mechanisms, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Molecular insights into an ancient form of Paget's disease of bone.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Anna DaroszewskaDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8TX, UK a.daroszewska@liverpool.ac.uk r.vanthof@liverpool.ac.uk.ORCID 0000-0002-6692-6610
Lorraine RoseRheumatic Diseases Unit, University of Edinburgh, Edinburgh EH4 2XU, UK.
Nadine SarsamDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8TX, UK.ORCID 0000-0002-3851-9823
Gemma CharlesworthDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8TX, UK.
Amanda PriorDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8TX, UK.
Kenneth RoseRheumatic Diseases Unit, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0003-4985-5539
Stuart H RalstonRheumatic Diseases Unit, University of Edinburgh, Edinburgh EH4 2XU, UK.
Robert J van 't HofDepartment of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8TX, UK a.daroszewska@liverpool.ac.uk r.vanthof@liverpool.ac.uk.ORCID 0000-0002-8193-6788
University of Liverpool · GBUniversity of Edinburgh · GB

Funding

Arthritis Research UK 19799Medical Research Council G0800933Medical Research Council MR/P020941/1Versus Arthritis 19799
6 · The paper itself

Abstract

Paget's disease of bone (PDB) is an age-related metabolic bone disorder, characterised by focally increased and disorganised bone remodelling initiated by abnormal and hyperactive osteoclasts. The germline P392L mutation of

Indexed as

AgingAnimalsBone and BonesBone ResorptionCalcification, PhysiologicDisease Models, AnimalMice, Inbred C57BLMice, Mutant StrainsMutationOrgan SizeOsteitis DeformansOsteoclastsPhenotypeSequestosome-1 ProteinZoledronic AcidSequestosome-1 ProteinSqstm1 protein, mouseZoledronic AcidAgeingAntiresorptivesBone morphometryGenetic animal modelsPaget's disease of boneZoledronic acid

Identifiers

PMID30154079
PMCPMC6177010
OpenAlexW2888746889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.