Evidence map›Paper›PMID 30153883›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2018

Interconnected clusters of invasive meningococcal disease due to

Alessandro Miglietta, Cecilia Fazio, Arianna Neri, Patrizio Pezzotti, Francesco Innocenti, Chiara Azzari, Gian Maria Rossolini, Maria Moriondo, Francesco Nieddu, Stefania Iannazzo and 6 more

Open access · diamondAbstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Evaluating the effect of targeted strategies as control tools for hypervirulent meningococcal C outbreaks: a case study from Tuscany, Italy, 2015 to 2016.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
    Article
  3. Article
  4. Reactive vaccination as control strategy for an outbreak of invasive meningococcal disease caused byEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022
    Article
  5. Vaccines and Senior Travellers.Frontiers in aging · 2021
    Review
  6. Article
  7. Detection of the United StatesEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. Serogroup CEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Alessandro MigliettaRegional Health Agency of Tuscany, Epidemiologic Observatory, Florence, Italy.
Cecilia FazioDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Arianna NeriDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Patrizio PezzottiDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Francesco InnocentiRegional Health Agency of Tuscany, Epidemiologic Observatory, Florence, Italy.
Chiara AzzariLaboratory of Immunology and Infectious Diseases, Anna Meyer Children's University Hospital, University of Florence, Florence, Italy.
Gian Maria RossoliniDepartment of Experimental and Clinical Medicine, University of Florence, and Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy.
Maria MoriondoLaboratory of Immunology and Infectious Diseases, Anna Meyer Children's University Hospital, University of Florence, Florence, Italy.
Francesco NiedduLaboratory of Immunology and Infectious Diseases, Anna Meyer Children's University Hospital, University of Florence, Florence, Italy.
Stefania IannazzoMinistry of Health, Directorate-General of health prevention, Rome, Italy.
Fortunato D'AnconaDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Francesco Paolo MaraglinoMinistry of Health, Directorate-General of health prevention, Rome, Italy.
Raniero GuerraMinistry of Health, Directorate-General of health prevention, Rome, Italy.
Giovanni RezzaDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Fabio VollerRegional Health Agency of Tuscany, Epidemiologic Observatory, Florence, Italy.
Paola StefanelliDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Istituto Superiore di Sanità · ITMinistero della Salute · ITUniversity of Florence · ITAgenzia Regionale di Sanità della Toscana · ITMeyer Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 2015 an increased incidence of invasive meningococcal disease due to serogroup-C (MenC) occurred in Tuscany, Italy. This led the Regional Health Authority of Tuscany to implement a reactive immunisation campaign and to launch an epidemiological field investigation aiming to address targeted immunisation interventions. In 2011-14, 10 MenC cases had been reported compared with 62 cases in 2015-16. The case fatality rate was 21% (n = 13) and 51 cases (82.3%) were confirmed as C:P1.5-1,10-8:F3-6:ST-11(cc11). Overall, 17 clusters were recognised. Six discos and four gay-venues were found to have a role as transmission-hotspots, having been attended by 20 and 14 cases in the 10 days before symptoms onset. Ten and three cases occurred, respectively, among men who have sex with men (MSM) and bisexual individuals, who were involved in 11 clusters. In addition, heterosexual cases (n = 5) attending gay-venues were also found. Secondary cases were not identified. Molecular typing indicated close relationship with MenC clusters recently described among gay, bisexual and other MSM in Europe and the United States, suggesting a possible international spread of the serogroup-C-variant P1.5-1,10-8:F3-6:ST-11(cc11) in this population-group; however, epidemiological links were not identified. In December 2016, a targeted vaccination campaign involving discos and lesbian, gay, bisexual, and transgender (LGBT) associations was implemented. During 2017, 10 cases of MenC occurred, compared with 32 and 30 cases reported in 2015 and 2016 respectively, suggesting the effectiveness of the reactive and targeted immunisation programmes.

Indexed as

BisexualityDisease OutbreaksHomosexuality, MaleAdolescentAdultAgedCarrier StateFemaleHumansImmunization ProgramsIncidenceItalyMaleMeningitis, MeningococcalMeningococcal InfectionsMeningococcal VaccinesMeningococcal Vaccinesserogroup C meningococcal conjugate vaccineclustersinvasive meningococcal disease serogroup Cmen who have sex with men (MSM)

Identifiers

PMID30153883
PMCPMC6113744
OpenAlexW2888574164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.