ArticleAddiction (Abingdon, England)2019
Indexing the 'dark side of addiction': substance-induced affective symptoms and alcohol use disorders.
Article in Addiction (Abingdon, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Association between alexithymia and substance use: A systematic review and meta-analysis.Scandinavian journal of psychology · 2022Pooled it
- Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder.Scientific reports · 2021Pooled it
- Influence of real-world cue exposure and mood states on drinking: testing neurobiological models of alcohol use disorder.Psychopharmacology · 2025Article
- Protective effects of ethnic enclaves: Testing pathways to alcohol use and use disorders in Mexican American young adults.American journal of community psychology · 2025Article
- Genetic factors associated with suicidal behaviors and alcohol use disorders in an American Indian population.Molecular psychiatry · 2024Article
- Comorbidity of anxiety/affective, conduct/antisocial, attention deficit, and alcohol use disorders with suicidal behaviors in an American Indian community sample of adults and adolescents.Journal of psychiatric research · 2023Article
- Event-related Oscillations to Emotional Faces are Related to a History of Internalizing Disorders.Clinical EEG and neuroscience · 2023Article
- Genetic Factors Associated with Suicidal Behaviors and Alcohol Use Disorders in an American Indian Population.Research square · 2023Article
- Directional associations between cannabis use and anxiety symptoms from late adolescence through young adulthood.Drug and alcohol dependence · 2022Article
- Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk.Behavioral sciences (Basel, Switzerland) · 2020Article
- Alcohol Induced Depression: Clinical, Biological and Genetic Features.Journal of clinical medicine · 2020Article
- Alcohol Use Disorder and Risk of Suicide in a Swedish Population-Based Cohort.The American journal of psychiatry · 2020Article
- Article
- Psychometric properties of the transaddiction craving triggers questionnaire in alcohol use disorder.International journal of methods in psychiatric research · 2020Article
- CR-19-0950: Event-related responses to alcohol-related stimuli in Mexican-American young adults: Relation to age, gender, comorbidity and "dark side" symptoms.Drug and alcohol dependence · 2019Article
- Observational
- Genetic loci for alcohol-related life events and substance-induced affective symptoms: indexing the "dark side" of addiction.Translational psychiatry · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsThe emergence of negative affective symptoms during the course of alcohol use disorders (AUDs) (e.g. 'dark side' symptoms) has been suggested theoretically; however, the description of their occurrence is limited. This study operationalized two negative affect symptoms and tested the strength of association between these phenotypes and (1) indicators of the clinical course of the severity of AUD, (2) comorbid Axis I psychiatric disorders, suicidal behaviors and trait neuroticism and (3) whether participants reported drinking to relieve the negative affective symptoms.
designA retrospective cross-sectional study was used to evaluate associations, using logistic regression, between the two negative affective symptoms and clinical measures of AUD severity and progression as well as comorbidity with other psychiatric disorders and conditions, adjusted for demographic characteristics.
settingUS community-based studies.
participantsA total of 2568 individuals with AUDs obtained from larger population studies that targeted individuals of European American (n = 1663), Mexican American and American Indian (n = 905) ancestry. MEASUREMENTS: Semi-Structured Assessment for the Genetics of Alcoholism was used to ascertain the two 'dark side' phenotypes, clinical diagnoses, the clinical course of AUD and associated symptoms. The two phenotypes were: (1) being anxious or depressed when trying to cut down or stop drinking and (2) experiencing disabling depression for more than 24 hours while drinking.
findingsBoth phenotypes were found to be rare in mild and moderate use disorder and highly prevalent in severe AUDs. Having an independent anxiety or affective disorder and elevated scores on trait neuroticism were also associated significantly with the occurrence of both symptoms, as was alcohol 'craving', elevated treatment-seeking, suicidal behaviors and drinking to relieve the symptoms.
conclusionsAffective symptoms are common in severe alcohol use disorders are associated with a history of independent affective/anxiety disorders, neuroticism and suicidal behaviors; and may promote further heavy drinking.
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