ArticleTransplantation2019
Kidney Transplant Outcomes in Recipients With Cognitive Impairment: A National Registry and Prospective Cohort Study.
Article in Transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- Dementia in Advanced Kidney Disease by Race and Ethnicity and Neighborhood Factors.Kidney international reports · 2026Article
- Cognitive function after kidney transplantation: longitudinal trajectories, associated factors, and clinical outcomes-a systematic review.International urology and nephrology · 2026Review
- Clarifying Molecular Mechanisms and Novel Strategies for Intervention of Uremia and Cognitive Decline.Kidney & blood pressure research · 2026Review
- Functional Status in Elderly Kidney Transplant Recipients: A Systematic Review Evaluating Physical Function, Frailty, and Cognitive Impairment as Predictors of Post-Transplant Outcomes.Diseases (Basel, Switzerland) · 2025Review
- Diagnosis and Management of Dementia for the Nephrology Clinician: A Review.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Review
- Economic Impact of Dementia After Kidney Transplantation: A Matched Cohort Analysis.Clinical transplantation · 2025Article
- Cognitive impairment in CKD patients: a guidance document by the CONNECT network.Clinical kidney journal · 2025Review
- Patient Perspectives on the Use of Aging Metrics for Kidney Transplant Decision-Making.Progress in transplantation (Aliso Viejo, Calif.) · 2024Article
- Pretransplant Cognitive Function and Kidney Transplant Outcomes: A Prospective Cohort Study.Kidney medicine · 2024Article
- Frailty, but not cognitive impairment, improves mortality risk prediction among those with chronic kidney disease-a nationally representative study.BMC nephrology · 2024Article
- Comprehensive geriatric assessment predicts listing for kidney transplant in patients with end-stage renal disease: a retrospective cohort study.BMC geriatrics · 2024Article
- Sleep duration and cognitive function among older adults with chronic kidney disease: results from the National Health and Nutrition Examination Survey (2011-2014).Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Secondary Hyperparathyroidism and Cognitive Decline.Current transplantation reports · 2023Article
- Post-kidney transplant body mass index trajectories are associated with graft loss and mortality.Clinical transplantation · 2023Article
- Subjective Cognition is Related to Patient-Reported Symptom Distress and Work Productivity Among Liver Transplant Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Screening of cognitive performance in kidney transplant recipients: a mini review.Frontiers in nephrology · 2023Review
- Cognitive Function and Kidney Transplantation: Putting Current Data into Clinical Perspective.Kidney medicine · 2022Article
- Neurocognitive Function Changes Following Kidney Transplant: A Prospective Study.Kidney medicine · 2022Article
- Pre-transplant cognitive screening is a poor predictor of post-transplant cognitive status.Clinical transplantation · 2022Article
- Neuropsychological Assessment of Cognitive Impairment in Kidney Transplantation (NAsKiT) and its related risk factors: a study protocol.Journal of nephrology · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCognitive impairment is common in patients with end-stage renal disease and is associated with poor outcomes on dialysis. We hypothesized that cognitive impairment might be associated with an increased risk of all-cause graft loss (ACGL) in kidney transplant (KT) recipients.
methodsUsing the Modified Mini-Mental State (3MS) examination, we measured global cognitive function at KT hospital admission in a prospective, 2-center cohort of 864 KT candidates (August 2009 to July 2016). We estimated the association between pre-KT cognitive impairment and ACGL using Cox regression, adjusting for recipient, donor, and transplant factors.
resultsIn living donor KT (LDKT) recipients, the prevalence was 3.3% for mild impairment (60 ≤ 3MS < 80) and 3.3% for severe impairment (3MS < 60). In deceased donor KT (DDKT) recipients, the prevalence was 9.8% for mild impairment and 2.6% for severe impairment. The LDKT recipients with cognitive impairment had substantially higher ACGL risk than unimpaired recipients (5-year ACGL: 45.5% vs 10.6%; P < 0.01; adjusted hazard ratio [aHR] any impairment, 5.40 (95% confidence interval [CI], 1.78-16.34; P < 0.01); aHR severe impairment, 5.57 (95% CI, 1.29-24.00; P = 0.02). Similarly, DDKT recipients with severe impairment had higher ACGL risk than recipients without severe impairment (5-year ACGL, 53.0% vs 24.2%; P = 0.04); aHR severe impairment, 2.92 (95% CI, 1.13-7.50; P = 0.03).
conclusionsGiven the elevated risk of ACGL among KT recipients with cognitive impairment observed in this 2-center cohort, research efforts should explore the mechanisms of graft loss and mortality associated with cognitive impairment and identify potential interventions to improve posttransplant survival.
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