Evidence map›Paper›PMID 30153151›Full record

ArticleClinical nuclear medicine2018

Predictive Value of FDG PET/CT to Detect Lymph Node Metastases in Cervical Cancer.

Laurie L Brunette, Shahram Bonyadlou, Lingyun Ji, Susan Groshen, Dena Shuster, Arjun Mehta, Richard Sposto, Koji Matsuo, Yvonne G Lin, Lynda D Roman

Open access · greenAbstract read
In one paragraph

Article in Clinical nuclear medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Diagnostic performance of [Frontiers in medicine · 2025
    Pooled it
  2. A dual-tracer approach for enhanced nodal staging in prostate cancer: the role of [European journal of nuclear medicine and molecular imaging · 2026
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  3. Diagnostic performance of quantitative measures from [European journal of nuclear medicine and molecular imaging · 2026
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  7. Predictive Value of Preoperative [International journal of general medicine · 2025
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  9. Comparison of the diagnostic value of [European journal of nuclear medicine and molecular imaging · 2024
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  10. Tumor and metastatic lymph nodes metabolic activity onAbdominal radiology (New York) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Laurie L Brunette
Shahram BonyadlouRadiology, and.
Lingyun Ji
Susan Groshen
Dena ShusterTufts University School of Dental Medicine, Boston, MA.
Arjun MehtaDepartment of Pathology, University of Southern California, Los Angeles, CA.
Richard Sposto
Koji Matsuo
Yvonne G LinFrom the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology.
Lynda D Roman
University of Southern California · USUSC Norris Comprehensive Cancer Center · USGynecologic Oncology Group · USTufts University · USUniversity Radiology · US

Funding

USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
NCI NIH HHS P30 CA014089
6 · The paper itself

Abstract

purposeThe aim of this study was to determine the prognostic significance of PET/CT findings in women with cervical cancer and describe the normalization of lymph node SUVmax (nSUVmax). MATERIALS AND

methodsA retrospective review was performed of 113 patients with cervical cancer who underwent a PET/CT before receiving definitive therapy. SUVmax measurements were normalized to the SUV of the pelvic blood pool. Patient, tumor, and PET/CT data were correlated to extracervical recurrence-free survival (ecRFS) and lymph node pathology.

resultsOf 113 patients, there were 23 (20%) extracervical recurrences. On univariate analysis, stage, histology, nSUVmax, and radiographic size of the primary tumor, and nSUVmax of the most hypermetabolic lymph node were significantly associated with ecRFS. On multivariable analysis, nSUVmax and radiographic size of the primary tumor remained associated with ecRFS (both P < 0.001). Sixty-six patients underwent pelvic, common iliac, and/or para-aortic nodal sampling. The sensitivity, specificity, false-negative, and false-positive rates of PET/CT for lymph node metastases were 53%, 75%, 6%, and 82%, respectively. On univariate analysis, nSUVmax, and radiographic size of the primary tumor, and nSUVmax of the most hypermetabolic lymph node, and radiographic size of the largest lymph node, were associated with the presence of at least one pathologically positive lymph node. On multivariable analysis, only the radiographic size of the largest lymph node remained significantly associated with lymph node metastases (P < 0.001).

conclusionsThe size and nSUVmax of the primary tumor were associated with ecRFS. PET/CT has a low false-negative rate but high false-positive rate for lymph node metastases.

Indexed as

Fluorodeoxyglucose F18Positron Emission Tomography Computed TomographyAdultFemaleHumansLymphatic MetastasisMiddle AgedPredictive Value of TestsPrognosisRetrospective StudiesSensitivity and SpecificityUterine Cervical NeoplasmsFluorodeoxyglucose F18

Identifiers

PMID30153151
PMCPMC7456572
OpenAlexW2888849447

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.