ArticleAnnals of neurology2018
Event-related deep brain stimulation of the subthalamic nucleus affects conflict processing.
Article in Annals of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Neurons of the human subthalamic nucleus engage with local delta frequency processes during action cancellation.Nature communications · 2026Article
- Changes in Functional Connectivity Relate to Modulation of Cognitive Control by Subthalamic Stimulation.Human brain mapping · 2024Article
- Subthalamic control of impulsive actions: insights from deep brain stimulation in Parkinson's disease.Brain : a journal of neurology · 2024Review
- Subthalamic stimulation causally modulates human voluntary decision-making to stay or go.NPJ Parkinson's disease · 2024Article
- Modeling impulsivity and risk aversion in the subthalamic nucleus with deep brain stimulation.Nature. Mental health · 2024Article
- Uncovering the neurophysiology of mood, motivation and behavioral symptoms in Parkinson's disease through intracranial recordings.NPJ Parkinson's disease · 2023Review
- Subthalamic Nucleus Activity during Cognitive Load and Gait Dysfunction in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Robust Removal of Slow Artifactual Dynamics Induced by Deep Brain Stimulation in Local Field Potential Recordings Using SVD-Based Adaptive Filtering.Bioengineering (Basel, Switzerland) · 2023Article
- Subthalamic Oscillatory Activity of Reward and Loss Processing Using the Monetary Incentive Delay Task in Parkinson Disease.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Unlocking potential: low frequency subthalamic nucleus stimulation enhances executive function in Parkinson's disease patients with postural instability/gait disturbance.Frontiers in neuroscience · 2023Article
- Editorial: The role of the basal ganglia in somatosensory-motor interactions: evidence from neurophysiology and behavior, volume II.Frontiers in human neuroscience · 2023Article
- Biophysical and Architectural Mechanisms of Subthalamic Theta under Response Conflict.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Reverse Visually Guided Reaching in Patients with Parkinson's Disease.Parkinson's disease · 2022Article
- Fronto-subthalamic phase synchronization and cross-frequency coupling during conflict processing.NeuroImage · 2021Article
- Emerging technologies for improved deep brain stimulation.Nature biotechnology · 2019Review
- Altered EEG alpha and theta oscillations characterize apathy in Parkinson's disease during incentivized movement.NeuroImage. Clinical · 2019Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveMany lines of evidence suggest that response conflict recruits brain regions in the cortical-basal ganglia system. Within the basal ganglia, deep brain recordings from the subthalamic nucleus (STN) have shown that conflict triggers a transient increase in low-frequency oscillations (LFOs; 2-8Hz). Here, we deployed a new method of delivering short trains of event-related deep brain stimulation (DBS) to the STN to test the causal role of the STN and its associated circuits in conflict-related processing.
methodsIn a double-blind design, we stimulated the STN in patients with Parkinson disease by locking brief trains of DBS to specific periods of the trial within a Stroop task.
resultsStimulation had a specific effect on conflict compared to nonconflict trials by relatively speeding responses on conflict trials (ie, reducing the Stroop effect, defined as the difference in reaction time between conflict and nonconflict trials) when it was delivered in the preresponse period in the preparation phase. Stimulation also increased errors when it was delivered early in the response window. This latter result corresponded to the timing of the conflict-induced increase in LFOs observed in the absence of stimulation but was not directly related to the reduction in the Stroop effect.
interpretationThese results support the theory that the time of LFO increase recorded from the STN corresponds to a conflict-processing function. They also provide one of the first demonstrations of event-related DBS of the STN in humans during a cognitive control paradigm. Ann Neurol 2018;84:515-526.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.