ArticleEpigenetics2018
Leukocyte telomere length and epigenetic-based mortality risk score: associations with all-cause mortality among older adults.
Article in Epigenetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The association of mean telomere length with all-cause, cerebrovascular and cardiovascular mortality.Bioscience reports · 2019Trial
- Causality between aging and interstitial lung disease: A bidirectional two-sample Mendelian randomization study.The Journal of international medical research · 2025Article
- DNA methylation-based telomere length is more strongly associated with long-term all-cause mortality than quantitative polymerase chain reaction-based telomere length among middle-aged and older hypertensive adults.Clinical epigenetics · 2025Article
- Skin Cancer: An Insight on its Association with Aging, Pathogenesis and Treatment Strategies.Current drug research reviews · 2024Review
- Causal relationship between depression and aging: a bidirectional two-sample Mendelian randomization study.Aging clinical and experimental research · 2023Article
- Causal association of epigenetic aging and COVID-19 severity and susceptibility: A bidirectional Mendelian randomization study.Frontiers in medicine · 2022Review
- Psychological and biological resilience modulates the effects of stress on epigenetic aging.Translational psychiatry · 2021Article
- "GrimAge," an epigenetic predictor of mortality, is accelerated in major depressive disorder.Translational psychiatry · 2021Article
- Article
- Blood-derived DNA methylation predictors of mortality discriminate tumor and healthy tissue in multiple organs.Molecular oncology · 2020Article
- Epigenetic predictors of all-cause mortality are associated with objective measures of neighborhood disadvantage in an urban population.Clinical epigenetics · 2020Article
- Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan.Aging · 2020Article
- Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives.Frontiers in genetics · 2020Review
- Comparative validation of an epigenetic mortality risk score with three aging biomarkers for predicting mortality risks among older adult males.International journal of epidemiology · 2019Article
- Accelerating research on biological aging and mental health: Current challenges and future directions.Psychoneuroendocrinology · 2019Review
- Oxidative stress and epigenetic mortality risk score: associations with all-cause mortality among elderly people.European journal of epidemiology · 2019Article
- Genetic Susceptibility to Chronic Kidney Disease - Some More Pieces for the Heritability Puzzle.Frontiers in genetics · 2019Review
- Association between telomere length in the DNA of peripheral blood leukocytes and the propofol dose in anesthesia induction: an observational study.Brazilian journal of anesthesiology (Elsevier)Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomere length (TL) has been established as a biomarker of aging and aging-related health outcomes, but showed only a weak or inconsistent association with all-cause mortality in previous epidemiological studies. Recently, an epigenetic 'mortality risk score' (MS) based on whole blood DNA methylation at 10 mortality-related CpG sites has been demonstrated to be strongly related to all-cause mortality at the population level. This study aimed to address the association between TL and this MS, and to assess and compare their associations with all-cause mortality. The MS was derived from the DNA methylation profiles measured by Illumina Human Methylation450K Beadchip and TL was measured by quantitative PCR at baseline among 1517 participants aged 50-75 of the German ESTHER cohort study. In cross-sectional bi- and multivariable analyses, the MS was strongly associated and showed monotonic dose-response relationships with TL (p-values <0.05). However, only the MS but not TL was associated with all-cause mortality during a median follow-up of 12.5 years. After controlling for potential covariates and TL, hazard ratios (95% CI) for all-cause mortality for low, moderate and high levels of the MS defined by 1, 2-5 and >5 CpG sites with aberrant methylation were 2.24 (1.13-4.41), 3.31 (1.76-6.22) and 6.33 (3.22-12.41) compared to a MS of 0, respectively. Our investigation shows that the epigenetic-based MS is strongly associated with TL, a broadly accepted aging biomarker, and at the same time shows much stronger associations with all-cause mortality than the latter.
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