ArticleClinical transplantation2018
Depressive symptoms, frailty, and adverse outcomes among kidney transplant recipients.
Article in Clinical transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Understanding frailty across the kidney transplant continuum: a comprehensive systematic review of recent evidence.International urology and nephrology · 2026Pooled it
- Effects of a Nursing Intervention Based on a Solution-Focused Approach on Renal Transplant Recipients' Anxiety, Depression, and Quality of Life.Journal of nursing management · 2023Trial
- Unmet Care Needs and Influencing Factors Among Young and Middle-Aged Kidney Transplant Recipients at Home in China: A Cross-Sectional Study.Nursing open · 2026Article
- Association of Myosteatosis and of Graft Loss after Kidney Transplantation: An International Observational Study.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Depressive and anxiety symptoms mediate the relationship between family support and alcohol relapse in transplant recipients with alcohol-associated liver disease.Scientific reports · 2025Article
- Pre- and Post-Kidney Transplant Abdominal Computed Tomography-Based Muscle Measurements and Post-KT Outcomes.Clinical transplantation · 2025Article
- Frailty Assessment Tools in Chronic Kidney Disease: A Systematic Review and Meta-analysis.Kidney medicine · 2025Article
- Frailty in Kidney Disease: A Comprehensive Review to Advance Its Clinical and Research Applications.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Review
- Frailty and post-transplant adverse outcomes among kidney transplant recipients A systematic review and meta-analysis.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024Article
- Frailty and depressive symptoms in older kidney transplant recipients: opportunities for collaboration between transplant nephrologists and geriatricians.BMC geriatrics · 2024Article
- Abdominal computed tomography measurements of body composition and waitlist mortality in kidney transplant candidates.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Baduanjin exercise intervention trial: research protocol of a randomised controlled trial for frail kidney transplant recipients.BMJ open · 2024Article
- Psychological Distress and Self-Management in CKD: A Cross-Sectional Study.Kidney medicine · 2023Article
- Use of frailty assessment instruments in nephrology populations: a scoping review.BMC geriatrics · 2023Article
- Transitions in frailty state 12 months after kidney transplantation: a prospective cohort study.Journal of nephrology · 2022Article
- Frailty and solid-organ transplant candidates: a scoping review.BMC geriatrics · 2022Article
- Psychosocial characteristics of patients evaluated for kidney transplant and associations with functional and frailty metrics at a veterans affairs hospital.Clinical transplantation · 2022Article
- The depressed frail phenotype as a risk factor for mortality in older adults: A prospective cohort in Peru.Heliyon · 2022Article
- Frailty and Kidney Transplantation: A Systematic Review and Meta-analysis.Transplantation direct · 2021Article
- Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Depressive symptoms and frailty are each independently associated with morbidity and mortality in kidney transplant (KT) recipients. We hypothesized that having both depressive symptoms and frailty would be synergistic and worse than the independent effect of each. In a multicenter cohort study of 773 KT recipients, we measured the Fried frailty phenotype and the modified 18-question Center for Epidemiologic Studies-Depression Scale (CES-D). Using adjusted Poisson regression and survival analysis, we tested whether depressive symptoms (CES-D score > 14) and frailty were associated with KT length of stay (LOS), death-censored graft failure (DCGF), and mortality. At KT admission, 10.0% of patients exhibited depressive symptoms, 16.3% were frail, and 3.6% had both. Recipients with depressive symptoms were more likely to be frail (aOR = 3.97, 95% CI: 2.28-6.91, P < 0.001). Recipients with both depressive symptoms and frailty had a 1.88 times (95% CI: 1.70-2.08, P < 0.001) longer LOS, 6.20-fold (95% CI:1.67-22.95, P < 0.01) increased risk of DCGF, and 2.62-fold (95% CI:1.03-6.70, P = 0.04) increased risk of mortality, compared to those who were nonfrail and without depressive symptoms. There was only evidence of synergistic effect of frailty and depressive symptoms on length of stay (P for interaction < 0.001). Interventions aimed at reducing pre-KT depressive symptoms and frailty should be explored for their impact on post-KT outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.