ArticleInternational journal of cancer2018
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
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In one paragraph
Article in International journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus.Neuro-oncology · 2023Pooled it
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- Screening of glioma susceptibility SNPs and construction of risk models based on machine learning algorithms.BMC neurology · 2025Article
- Understanding Neovascularization in Glioblastoma: Insights from the Current Literature.International journal of molecular sciences · 2025Review
- Regression and machine learning approaches identify potential risk factors for glioblastoma multiforme.Brain communications · 2025Article
- The arch myth: investigating the impact of flat foot on vertical jump height: a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2024Article
- Epidemiology of malignant brain tumors in Genova, Italy. 1993-2017.Scientific reports · 2024Article
- Paromomycin targets HDAC1-mediated SUMOylation and IGF1R translocation in glioblastoma.Frontiers in pharmacology · 2024Article
- Inherited genetics of adult diffuse glioma and polygenic risk scores-a review.Neuro-oncology practice · 2022Review
- Glioblastoma in the Elderly: Review of Molecular and Therapeutic Aspects.Biomedicines · 2022Review
- Newly Diagnosed Glioblastoma in Elderly Patients.Current oncology reports · 2022Review
- From GWAS to drug screening: repurposing antipsychotics for glioblastoma.Journal of translational medicine · 2022Article
- Article
- Racial/ethnic disparities in treatment pattern and time to treatment for adults with glioblastoma in the US.Journal of neuro-oncology · 2021Article
- Identification of Hub Gene GRIN1 Correlated with Histological Grade and Prognosis of Glioma by Weighted Gene Coexpression Network Analysis.BioMed research international · 2021Article
- Clinical Significance of Various Classification Standards of Age Groups in Predicting Survival of Patients with Glioblastoma.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Risk factors for childhood and adult primary brain tumors.Neuro-oncology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 20 institutions in 5 countries.
Quinn T OstromDepartment of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
Ben KinnersleyDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.
Georgina ArmstrongDepartment of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
Terri RiceDepartment of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco, California.
Yanwen ChenCase Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
John K WienckeDepartment of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco, California.
Lucie S McCoyDepartment of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco, California.
Helen M HansenDepartment of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco, California.
Christopher I AmosBaylor College of Medicine, Institute for Clinical and Translational Research, Houston, Texas.
Jonine L BernsteinDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Elizabeth B ClausSchool of Public Health, Yale University, New Haven, Connecticut.
Jeanette E Eckel-PassowDivision of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota.
Dora Il'yasovaDepartment of Epidemiology and Biostatistics, School of Public Health, Georgia State University, Atlanta, Georgia.
Christoffer JohansenOncology clinic, Finsen Center, Rigshospitalet and Survivorship Research Unit, The Danish Cancer Society Research Center, Copenhagen, Denmark.
Daniel H LachanceDepartment of Neurology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, Minnesota.
Rose K LaiDepartments of Neurology and Preventive Medicine, Keck School of Medicine, University of Southern California, California, Los Angeles.
Ryan T MerrellDepartment of Neurology, NorthShore University HealthSystem, Evanston, Illinois.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Siegal SadetzkiCancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Joellen M SchildkrautDepartment of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia.
Sanjay SheteDepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas.
Joshua B RubinDepartments of Pediatrics and Neuroscience, Washington University School of Medicine, St. Louis, Missouri.
Ulrika AnderssonDepartment of Radiation Sciences, Faculty of Medicine, Umeå University, Umeå, Sweden.
Preetha RajaramanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Martha S LinetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Zhaoming WangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Meredith YeagerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
GliomaScan consortium
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.
Robert B JenkinsDepartment of Laboratory Medicine and Pathology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, Rochester, Minnesota.
Margaret R WrenschDepartment of Neurological Surgery and Institute of Human Genetics, School of Medicine, University of California, San Francisco, San Francisco, California.
Beatrice MelinDepartment of Radiation Sciences, Faculty of Medicine, Umeå University, Umeå, Sweden.
Melissa L BondyDepartment of Medicine, Section of Epidemiology and Population Sciences, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas.
Jill S Barnholtz-SloanCase Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Case Western Reserve University · USUniversity of California, San Francisco · USBaylor College of Medicine · USDivision of Cancer Epidemiology and GeneticsInstitute of Cancer Research · GBMemorial Sloan Kettering Cancer Center · USNeurological Surgery · USScience Applications International Corporation (United States) · USUmeå University · SEGeorgia Department of Public Health · USHouston Institute for Clinical Research · USMayo Clinic · USMayo Clinic in Florida · USNational Cancer Institute · USNorthShore University HealthSystem · USRigshospitalet · DKTel Aviv University · ILThe University of Texas MD Anderson Cancer Center · USUniversity of Southern California · USUniversity of Virginia · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MUCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2MTumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MTissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang · 2002 to 2026
$57.4MCALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5MGENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5MInternational Case Control Study of Malignant GliomaR01CA139020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2010 to 2015
$16.0MImmune epigenetic biomarkers of survival in glioma epidemiologyR01CA207360 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 2017 to 2021
$3.8MThe NYU Women's Health StudyUM1CA182934 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ZELENIUCH-JAQUOTTE, ANNE · 2015 to 2019
$3.7MBiomarkers of survival in glioma epidemiologyR01CA126831 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 2008 to 2013
$2.5MCDC HHSCDC HHS U58DP003862-01NCATS NIH HHSNCCDPHP CDC HHS U58 DP003862NCI NIH HHS 30CA125123P50097257R01CA126831R01CA139020R01CA52689NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000140CNCI NIH HHS HHSN261201000140CPNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA126831NCI NIH HHS R01 CA139020NCI NIH HHS R01 CA207360NCI NIH HHS UM1 CA182934NCRR NIH HHS UL1 RR024131NIH HHS P30CA125123NIH HHS P50097257NIH HHS P50CA097257NIH HHS R01CA126831NIH HHS R01CA139020NIH HHS R01CA52689Wellcome TrustWellcome Trust UK10K
Abstract
Glioblastoma (GBM) is the most common malignant brain tumor in the United States. Incidence of GBM increases with age, and younger age-at-diagnosis is significantly associated with improved prognosis. While the relationship between candidate GBM risk SNPs and age-at-diagnosis has been explored, genome-wide association studies (GWAS) have not previously been stratified by age. Potential age-specific genetic effects were assessed in autosomal SNPs for GBM patients using data from four previous GWAS. Using age distribution tertiles (18-53, 54-64, 65+) datasets were analyzed using age-stratified logistic regression to generate p values, odds ratios (OR), and 95% confidence intervals (95%CI), and then combined using meta-analysis. There were 4,512 total GBM cases, and 10,582 controls used for analysis. Significant associations were detected at two previously identified SNPs in 7p11.2 (rs723527 [p
Indexed as
AdolescentAdultAgedAge FactorsBrain NeoplasmsCase-Control StudiesFemaleGenome-Wide Association StudyGlioblastomaHumansMaleMiddle AgedNeoplasm GradingPolymorphism, Single NucleotideYoung Adultagebrain tumorsglioma
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.