ArticleInternational journal for numerical methods in biomedical engineering2018
Assessment of wall stresses and mechanical heart power in the left ventricle: Finite element modeling versus Laplace analysis.
Article in International journal for numerical methods in biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- A modelling study of right ventricular growth with valvular regurgitation.Biomechanics and modeling in mechanobiology · 2026Article
- New Genetic Loci Implicated in Cardiac Morphology and Function Using Three-Dimensional Population Phenotyping.Circulation. Genomic and precision medicine · 2025Article
- Acute effects of mechanical dyssynchrony on left ventricular function and coronary perfusion.Frontiers in bioengineering and biotechnology · 2025Article
- The geometric evolution of aortic dissections: Predicting surgical success using fluctuations in integrated Gaussian curvature.PLoS computational biology · 2024Article
- Comparison of two ellipsoidal models for the estimation of left ventricular end-systolic stress in patients with significant coronary artery disease.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Article
- Novel Methodology for Measuring Regional Myocardial Efficiency.IEEE transactions on medical imaging · 2021Article
- Non-invasive Global and Regional Myocardial Work Predicts High-Risk Stable Coronary Artery Disease Patients With Normal Segmental Wall Motion and Left Ventricular Function.Frontiers in cardiovascular medicine · 2021Article
- Transmural Distribution of Coronary Perfusion and Myocardial Work Density Due to Alterations in Ventricular Loading, Geometry and Contractility.Frontiers in physiology · 2021Article
- Personalization of electro-mechanical models of the pressure-overloaded left ventricle: fitting of Windkessel-type afterload models.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- The impact of wall thickness and curvature on wall stress in patient-specific electromechanical models of the left atrium.Biomechanics and modeling in mechanobiology · 2020Article
- The Physics of Fluid Dynamics Applied to Vascular Ulcers and Its Impact on Nursing Care.Healthcare (Basel, Switzerland) · 2020Article
- A publicly available virtual cohort of four-chamber heart meshes for cardiac electro-mechanics simulations.PloS one · 2020Article
- Fluid Structure Interaction on Paravalvular Leakage of Transcatheter Aortic Valve Implantation Related to Aortic Stenosis: A Patient-Specific Case.Computational and mathematical methods in medicine · 2020Article
- Surrogates for myocardial power and power efficiency in patients with aortic valve disease.Scientific reports · 2019Article
- A magnetics-based approach for fine-tuning afterload in engineered heart tissues.ACS biomaterials science & engineering · 2019Article
- Assessment of wall stresses and mechanical heart power in the left ventricle: Finite element modeling versus Laplace analysis.International journal for numerical methods in biomedical engineering · 2018Article
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9 authors.
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Abstract
introductionStenotic aortic valve disease (AS) causes pressure overload of the left ventricle (LV) that may trigger adverse remodeling and precipitate progression towards heart failure (HF). As myocardial energetics can be impaired during AS, LV wall stresses and biomechanical power provide a complementary view of LV performance that may aide in better assessing the state of disease.
objectivesUsing a high-resolution electro-mechanical (EM) in silico model of the LV as a reference, we evaluated clinically feasible Laplace-based methods for assessing global LV wall stresses and biomechanical power.
methodsWe used N = 4 in silico finite element (FE) EM models of LV and aorta of patients suffering from AS. All models were personalized with clinical data under pretreatment conditions. Left ventricle wall stresses and biomechanical power were computed accurately from FE kinematic data and compared with Laplace-based estimation methods, which were applied to the same FE model data. RESULTS AND
conclusionLaplace estimates of LV wall stress are able to provide a rough approximation of global mean stress in the circumferential-longitudinal plane of the LV. However, according to FE results, spatial heterogeneity of stresses in the LV wall is significant, leading to major discrepancies between local stresses and global mean stress. Assessment of mechanical power with Laplace methods is feasible, but these are inferior in accuracy compared with FE models. The accurate assessment of stress and power density distribution in the LV wall is only feasible based on patient-specific FE modeling.
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