ArticleAnnals of the New York Academy of Sciences2018
Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs.
Article in Annals of the New York Academy of Sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 150 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevalence of Thiamine Deficiency in Hospitalized Non-Alcoholic Veterans
A Seamless Phase 2A-Phase 2B Randomized Double-Blind Placebo- Controlled Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)
Who cites it
150 citing papers in PubMed, 4 syntheses or guidelines pooled it, 311 citations in OpenAlex.
- Wernicke encephalopathy in non-alcoholic patients following gastrointestinal procedures: a systematic review.Frontiers in surgery · 2026Pooled it
- A Systematic Review of Thiamine Supplementation in Improving Diabetes and Its Related Cardiovascular Dysfunction.International journal of molecular sciences · 2025Pooled it
- Prevalence of thiamine deficiency in anorexia nervosa: a systematic review and narrative synthesis.European child & adolescent psychiatry · 2025Pooled it
- Micronutrient Deficiencies Presenting with Optic Disc Swelling Associated with or without Intracranial Hypertension: A Systematic Review.Nutrients · 2022Pooled it
- Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin BEuropean journal of nutrition · 2022Trial
- Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations: a randomized controlled trial.The American journal of clinical nutrition · 2021Trial
- Macro- and Micronutrients in Milk from Healthy Cambodian Mothers: Status and Interrelations.The Journal of nutrition · 2020Trial
- A Randomized Pilot Trial to Evaluate the Bioavailability of Natural versus Synthetic Vitamin B Complexes in Healthy Humans and Their Effects on Homocysteine, Oxidative Stress, and Antioxidant Levels.Oxidative medicine and cellular longevity · 2019Trial
- Functional thiamine deficiency in patients with chronic kidney disease in Northeast Thailand.Future science OA · 2026Article
- Inequity on energy and nutrient consumption among urban residents of Ethiopia may impact the effectiveness of large-scale food fortification.The British journal of nutrition · 2026Article
- Thiamine Deficiency in Hospitalized Veterans Without Alcohol Use Disorder: Prevalence, Biomarker Assessment, and Clinical Characteristics.Diseases (Basel, Switzerland) · 2026Article
- Adverse events associated with drug-related thiamine deficiency: A pharmacovigilance study.JPEN. Journal of parenteral and enteral nutrition · 2026Article
- Article
- Targeting risk factors and strategies for prevention of peripheral neuropathy: focus on B-vitamin deficiencies and metabolic diseases.Neurological research and practice · 2026Review
- Thiamine and Micronutrient Deficiencies in Hospitalized Veterans Without Alcohol Use Disorder.Diseases (Basel, Switzerland) · 2026Article
- Reassessing Transketolase Assays: Methodological Considerations for Detecting Functional Thiamine Deficiency.Annals of the New York Academy of Sciences · 2026Review
- Plasma vitamin profiles and their associations with metabolic health and mental wellbeing in midlife Asian women.Scientific reports · 2026Article
- B Vitamin Deficiencies and Associated Neuropathies.Current nutrition reports · 2026Review
- Dietary thiaminase alters morphology and decreases swimming performance of lake trout (Salvelinus namaycush).Scientific reports · 2026Article
- Abdominal Pain and Hyperlactatemia in Thiamine Deficiency: A Case Report.Case reports in pediatrics · 2026Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 19 institutions in 9 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thiamine is an essential micronutrient that plays a key role in energy metabolism. Many populations worldwide may be at risk of clinical or subclinical thiamine deficiencies, due to famine, reliance on staple crops with low thiamine content, or food preparation practices, such as milling grains and washing milled rice. Clinical manifestations of thiamine deficiency are variable; this, along with the lack of a readily accessible and widely agreed upon biomarker of thiamine status, complicates efforts to diagnose thiamine deficiency and assess its global prevalence. Strategies to identify regions at risk of thiamine deficiency through proxy measures, such as analysis of food balance sheet data and month-specific infant mortality rates, may be valuable for understanding the scope of thiamine deficiency. Urgent public health responses are warranted in high-risk regions, considering the contribution of thiamine deficiency to infant mortality and research suggesting that even subclinical thiamine deficiency in childhood may have lifelong neurodevelopmental consequences. Food fortification and maternal and/or infant thiamine supplementation have proven effective in raising thiamine status and reducing the incidence of infantile beriberi in regions where thiamine deficiency is prevalent, but trial data are limited. Efforts to determine culturally and environmentally appropriate food vehicles for thiamine fortification are ongoing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.