ArticleJournal of materials science. Materials in medicine2018
Dual-crosslinked homogeneous alginate microspheres for mesenchymal stem cell encapsulation.
Article in Journal of materials science. Materials in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Impact of Whey Protein on the Physico-Mechanical Properties of Alginate Dialdehyde Scaffolds and Cell Adhesion for Cultivated Meat Applications.Food hydrocolloids · 2026Article
- Optimization of mouse oocyte vitrification through microencapsulation in sodium alginate hydrogel.Journal of assisted reproduction and genetics · 2025Article
- Reversible Stiffening of Biopolymeric Hybrid Networks by Dynamically Switching Cross-LinksACS applied materials & interfaces · 2025Article
- Genipin cross-linked gelatin hydrogel for encapsulating wharton jelly mesenchymal stem cells and basic fibroblast growth factor delivery in vocal fold regeneration.Frontiers in cell and developmental biology · 2024Article
- Dual-Crosslinked Alginate-Based Hydrogels with Tunable Mechanical Properties for Cultured Meat.Foods (Basel, Switzerland) · 2022Article
- Development of an Injectable Shear-Thinning Nanocomposite Hydrogel for Cardiac Tissue Engineering.Gels (Basel, Switzerland) · 2022Article
- Bio-inspired green light crosslinked alginate-heparin hydrogels support HUVEC tube formation.Journal of the mechanical behavior of biomedical materials · 2022Article
- Biomaterial-Assisted Regenerative Medicine.International journal of molecular sciences · 2021Review
- Medicated Hydroxyapatite/Collagen Hybrid Scaffolds for Bone Regeneration and Local Antimicrobial Therapy to Prevent Bone Infections.Pharmaceutics · 2021Article
- A Versatile Microencapsulation Platform for Hyaluronic Acid and Polyethylene Glycol.Tissue engineering. Part A · 2021Article
- A Low-Cost Open Source Device for Cell Microencapsulation.Materials (Basel, Switzerland) · 2020Article
- Enhanced single-cell encapsulation in microfluidic devices: From droplet generation to single-cell analysis.Biomicrofluidics · 2020Review
- Applications of alginate microspheres in therapeutics delivery and cell culture: Past, present and future.International journal of pharmaceutics · 2019Review
- Dual Crosslinked Methacrylated Alginate Hydrogel Micron Fibers and Tissue Constructs for Cell Biology.Marine drugs · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A smart hydrogel material was used in combination with custom microfluidic devices (MFDs) to create microspheres for human mesenchymal stem cell (MSC) encapsulation. Methods for fabricating homogeneous stimuli-responsive microspheres for MSC encapsulation and cell delivery have gained interest to increase viability and manipulate microencapsulation within microspheres 10-1000 µm in diameter. Herein, MFDs were combined with non-toxic smart hydrogel materials to tune both the size and mechanics of the microspheres. Traditional hydrogels have a single input/stimulus for crosslinking, utilize potentially toxic ultraviolet radiation, and fail to mimic surrounding musculoskeletal tissue mechanics. Thus, it is highly beneficial to encapsulate MSCs inside a mechanically-stable microsphere made from naturally-derived materials. The objectives of this research were to optimize microsphere fabrication techniques using custom microfluidic devices (MFDs), and to encapsulate viable MSCs within visible-light crosslinked smart-alginate microspheres, with tunable mechanical properties. Microsphere production was characterized optically, and MSC viability, post-encapsulation, was verified using a standard florescence assay. Cell viability was maintained in chemically-modified alginate homogenous microspheres post encapsulation, and after subsequent crosslinking via green light exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.