ArticleAnnals of biomedical engineering2019
Sinus Hemodynamics Variation with Tilted Transcatheter Aortic Valve Deployments.
Article in Annals of biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 45 citations in OpenAlex.
- Transcatheter aortic valve canting creates cusp-specific thrombogenic microenvironments through altered sinus hemodynamics.JTCVS structural and endovascular · 2026Article
- Periprocedural evaluation of patients with BAV stenosis undergoing TAVR: a machine learning-based study.Open heart · 2026Article
- Redo-Transcatheter Aortic Valve Implantation (Redo-TAVI)-Pilot Study from Multicentre Nationwide Registry.Journal of clinical medicine · 2025Article
- Neo-Sinus Washout Time Following Transcatheter Aortic Valve Replacement and Hemodynamic Outcomes.Structural heart : the journal of the Heart Team · 2025Article
- Analysis of Energy and Pressure in the Sinus with Different Blood Pressures after Bioprosthetic Aortic Valve Replacement.Annals of biomedical engineering · 2024Article
- In Vitro Comparison of a Closed and Semi-closed Leaflet Design for Adult and Pediatric Transcatheter Heart Valves.Annals of biomedical engineering · 2024Article
- Effect of Blood Pressure Levels on Sinus Hemodynamics in Relation to Calcification After Bioprosthetic Aortic Valve Replacement.Annals of biomedical engineering · 2024Article
- Differential Impact of Blood Pressure Control Targets on Epicardial Coronary Flow After Transcatheter Aortic Valve Replacement.Structural heart : the journal of the Heart Team · 2024Article
- Transcatheter Aortic Valve Therapy for Bicuspid Aortic Valve Stenosis.Journal of cardiovascular development and disease · 2023Review
- Transcatheter aortic valve replacement for bicuspid aortic valve disease: does conventional surgery have a future?Annals of cardiothoracic surgery · 2022Review
- Flow Dynamics in Anomalous Aortic Origin of a Coronary Artery in Children: Importance of the Intramural Segment.Seminars in thoracic and cardiovascular surgery · 2022Article
- Treatment of Bicuspid Aortic Valve Stenosis with TAVR: Filling Knowledge Gaps Towards Reducing Complications.Current cardiology reports · 2022Review
- Predictive Model for Thrombus Formation After Transcatheter Valve Replacement.Cardiovascular engineering and technology · 2021Article
- Three-dimensional printing to plan intracardiac operations.JTCVS techniques · 2021Article
- The hemodynamics of transcatheter aortic valves in transcatheter aortic valves.The Journal of thoracic and cardiovascular surgery · 2021Article
- Effect of Left and Right Coronary Flow Waveforms on Aortic Sinus Hemodynamics and Leaflet Shear Stress: Correlation with Calcification Locations.Annals of biomedical engineering · 2020Article
- Sinus Hemodynamics After Transcatheter Aortic Valve in Transcatheter Aortic Valve.The Annals of thoracic surgery · 2020Article
- Clinical situations for which 3D printing is considered an appropriate representation or extension of data contained in a medical imaging examination: adult cardiac conditions.3D printing in medicine · 2020Article
- Utility of Three-Dimensional (3D) Modeling for Planning Structural Heart Interventions (with an Emphasis on Valvular Heart Disease).Current cardiology reports · 2020Review
- Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine Model.JACC. Basic to translational science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Leaflet thrombosis is a complication associated with transcatheter aortic valve (TAV) replacement (TAVR) correlated with sinus flow stasis. Sinus hemodynamics are important because they dictate shear stress and washout necessary to avoid stasis on TAV leaflets. Sinus flow is controlled by TAV axial deployment position but little is known regarding TAV axis misalignment effect. This study aims to elucidate TAV angular misalignment with respect to aortic root axis effect on sinus flow stasis potentially leading to leaflet thrombosis. Sinus hemodynamics were assessed in vitro using particle-image velocimetry in three different angular misalignments with respect to aorta axis: untilted, tilted away from the sinus and tilted towards sinus. A 26 mm Edwards SAPIEN3 was implanted in a 3D printed model of an anatomically realistic aortic root. TAV hemodynamics, sinus vortex tracking, leaflet shear stress probability density functions, and sinus blood time to washout were calculated. While pressure gradients differed insignificantly, blood velocity and vorticity decreased significantly in both tilted cases sinuses. Shear stress probability near the leaflet decreases with tilt indicating stasis. TAV tilted away from the sinus is the most unfavorable scenario with poor washout. TAV axial misalignment adds to factors list that could influence leaflet thrombosis risk through modifying sinus hemodynamics and washout.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.