Evidence map›Paper›PMID 30151710›Full record

ReviewHerz2019

Regulation of geminin by neuropeptide Y in vascular smooth muscle cell proliferation : A current review.

S-Y Liang, Y-L Zhou, M-Q Shu, S Lin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Herz, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

S-Y LiangDepartment of Cardiology, Southwest Hospital, Third Military Medical University, No. 30 Gaotanyan, Shapingba, 400038, Chongqing, China.
Y-L ZhouDepartment of Cardiology, Southwest Hospital, Third Military Medical University, No. 30 Gaotanyan, Shapingba, 400038, Chongqing, China.
M-Q ShuDepartment of Cardiology, Southwest Hospital, Third Military Medical University, No. 30 Gaotanyan, Shapingba, 400038, Chongqing, China. maoqinshu@yeah.net.
S LinDepartment of Cardiology, Southwest Hospital, Third Military Medical University, No. 30 Gaotanyan, Shapingba, 400038, Chongqing, China. shulin1956@126.com.
Southwest Hospital · CNUniversity of Wollongong · AU

Funding

National Natural Science Foundation of China 815703960National Natural Science Foundation of China 81670402
6 · The paper itself

Abstract

Geminin, a key regulator of DNA replication licensing in the cell cycle, plays an essential role in determining the fate of cells via suppression of cell proliferation and cellular differentiation. Neuropeptide Y (NPY) intensifies the proliferation of vascular smooth muscle cells (VSMCs) directly by binding with Y1 receptors. In vitro experiments have shown that stimulation of NPY on VSMCs via regulation of geminin is a double-edged sword. Given that the proliferation and the phenotypic transformation of VSMCs increase the risk for progression of atherosclerosis, we focus on the role of geminin interference in determining the fate of VSMCs. Furthermore, we discuss the therapeutic potential of peripheral neurotransmitter interference, thus pointing toward future research directions in the treatment of atherosclerosis.

Indexed as

GemininMuscle, Smooth, VascularNeuropeptide YCell ProliferationMyocytes, Smooth MuscleGemininNeuropeptide YAtherosclerosisCell cycleDNA replicationNeuropeptide YNeurotransmitter

Identifiers

PMID30151710
OpenAlexW2889345525

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.