ReviewEsophagus : official journal of the Japan Esophageal Society2019
Interactions between Helicobacter pylori and gastroesophageal reflux disease.
Review in Esophagus : official journal of the Japan Esophageal Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Effects of Helicobacter pylori infection on gastric cancer, obesity and esophageal diseases: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Mendelian randomization study of gastroesophageal reflux disease and major depression.PloS one · 2023Pooled it
- Age threshold and symptoms are useful for scheduling upper endoscopy in clinical practice.Internal and emergency medicine · 2026Article
- Cross-organ microbes modulate host upper gastrointestinal health and disease via the oral-gastric microbiome axis.Frontiers in cellular and infection microbiology · 2026Review
- Effects of IntragastricJournal of clinical medicine · 2025Article
- Elevated serum pepsinogen level predicts postoperative nausea and vomiting and pain in females with obesity following laparoscopic sleeve gastrectomy.International journal of obesity (2005) · 2025Article
- The Prevalence of Gastroesophageal Reflux Disease (GERD) in H. pylori-Positive and -Negative Patients.Cureus · 2024Article
- Effectiveness of serological markers of gastric mucosal atrophy in the gastric precancer screening and in cancer prevention.World journal of gastrointestinal endoscopy · 2024Article
- Immunoglobulin G-mediated food intolerance and metabolic syndrome influence the occurrence of reflux esophagitis inWorld journal of gastroenterology · 2024Article
- Relationship betweenPrzeglad gastroenterologiczny · 2024Article
- Review
- Effects ofFrontiers in cellular and infection microbiology · 2023Article
- The association between helicobacter pylori infection and erosive gastroesophageal reflux disease; a cross-sectional study.BMC infectious diseases · 2022Article
- Inverse correlation between gastroesophageal reflux disease and atrophic gastritis assessed by endoscopy and serology.World journal of gastroenterology · 2022Article
- Review
- Relationship AmongSisli Etfal Hastanesi tip bulteni · 2022Article
- Definition of Mucosal Breaks in the Era of Magnifying Endoscopy with Narrow-Band Imaging.Gastroenterology research and practice · 2022Article
- Phenotypic and Genotypic Analysis of ResistantDiagnostics (Basel, Switzerland) · 2020Article
- Effect of Helicobacter pylori eradication on reflux esophagitis and GERD symptoms after endoscopic resection of gastric neoplasm: a single-center prospective study.BMC gastroenterology · 2020Article
- Dabigatran-induced esophagitis: A case report.Medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interactions between Helicobacter Pylori (HP) and gastroesophageal reflux disease (GERD) are a complex issue. Several pathophysiological factors influence the development and the course of GERD, HP infection might be only one of these. Many studies emphasize the co-existence of these diseases. HP infection could contribute to GERD through both a protective and an aggressive role. Gastric acid secretion is a key factor in the pathophysiology of reflux esophagitis. Depending on the type of gastritis related to HP, acid secretion may either increase or decrease. Gastritis in corpus leads to hypoacidity, while antrum gastritis leads to hyperacidity. In cases of antral gastritis and duodenal ulcers which have hyperacidity, the expectation is an improvement in pre-existing reflux esophagitis after eradication of HP. In adults, HP infection is often associated with atrophic gastritis in the corpus. Atrophic gastritis may protect against GERD. Pangastritis which leads to gastric atrophy is commonly associated with CagA strains of HP and it causes more severe gastric inflammation. In case of HP-positive corpus gastritis in the stomach, pangastritis, and atrophic gastritis, reflux esophagitis occurs frequently after eradication of HP. Nonetheless, as a predisposing disease of gastric cancer, HP should be treated. In conclusion, as the determinative factors affecting GERD involving in HP, detailed data on the location of gastric inflammation and CagA positivity should be obtained by the studies at future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.