ArticleJournal of the Endocrine Society2018
Notch-1 Signaling Activation and Progesterone Receptor Expression in Ectopic Lesions of Women With Endometriosis.
Article in Journal of the Endocrine Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells.Reproductive sciences (Thousand Oaks, Calif.) · 2020Trial
- Interactions Between Neurotrophins and Ovarian Steroids in Endometriosis and Their Implications for Neuroangiogenesis: A Narrative Review.Current issues in molecular biology · 2026Review
- NOTCH1- and CD117-Positive Stem Cells in Human Endometriosis and Adenomyosis Lesions.Diagnostics (Basel, Switzerland) · 2024Article
- Association betweenCurrent issues in molecular biology · 2024Article
- Review
- A Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Progesterone Resistance in Endometriosis: Current Evidence and Putative Mechanisms.International journal of molecular sciences · 2023Review
- Impact of Musashi-1 and Musashi-2 Double Knockdown on Notch Signaling and the Pathogenesis of Endometriosis.International journal of molecular sciences · 2022Article
- Review
- Notch signaling in reproduction.Trends in endocrinology and metabolism: TEM · 2021Review
- Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10.Journal of molecular endocrinology · 2021Article
- Lesion Genotype Modifies High-Fat Diet Effects on Endometriosis Development in Mice.Frontiers in physiology · 2021Article
- Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?International journal of molecular sciences · 2019Review
- Progesterone resistance in endometriosis: A pathophysiological perspective and potential treatment alternatives.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
contextProgesterone (P) resistance is a hallmark of endometriosis, but the underlying mechanism(s) for loss of P sensitivity leading to lesion establishment remains poorly understood.
objectiveTo evaluate the association between Notch-1 signaling activation and P resistance in the progression of endometriosis.
designCase control study; archived formalin-fixed, paraffin-embedded tissues.
settingUniversity hospitals (United States, Taiwan). PATIENTS: Women with endometriosis; human endometrial stromal cell line (HESC).
interventionEutopic endometria (EU) and ectopic lesions (ECs) were collected from surgically diagnosed patients. Archived tissue sections of EU and ECs were identified. HESCs were treated with OUTCOME MEASURES: Tissues were analyzed for Notch Intra-Cellular Domain 1 (NICD1) and progesterone receptor (PGR) protein expression by immunohistochemistry and for transcript levels of NICD1 target genes
resultsNuclear-localized stromal NICD1 protein levels were inversely associated with those of total PGR in EU and ECs. Stromal ECs displayed higher
conclusionsAberrant Notch-1 activation is associated with decreased PGR that contributes to P resistance in endometriosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.