ArticleOpen forum infectious diseases2018
Gut Microbiota and Clinical Features Distinguish Colonization With
Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluation of the Association Between Gastric Acid Suppression and Risk of Intestinal Colonization With Multidrug-Resistant Microorganisms: A Systematic Review and Meta-analysis.JAMA internal medicine · 2020Pooled it
- Gut Microbiome-Based Strategies for the Control of Carbapenem-Resistant Enterobacteriaceae.Journal of microbiology and biotechnology · 2025Review
- Gut community structure as a risk factor for infection inmSystems · 2024Article
- The Roles of a Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Risk factors of carbapenemase-producing Enterobacterales acquisition among adult intensive care unit patients at a Kentucky Academic Medical Center.Infection prevention in practice · 2023Article
- Active surveillance for carbapenemase-producingBMJ open · 2021Article
- Prolonged Carriage of Carbapenemase-ProducingJournal of clinical medicine · 2021Article
- Epidemiological and Microbiome Associations BetweenOpen forum infectious diseases · 2020Article
- Increased Relative Abundance of Klebsiella pneumoniae Carbapenemase-producing Klebsiella pneumoniae Within the Gut Microbiota Is Associated With Risk of Bloodstream Infection in Long-term Acute Care Hospital Patients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundIdentification of gut microbiota features associated with antibiotic-resistant bacterial colonization may reveal new infection prevention targets.
methodsWe conducted a matched, case-control study of long-term acute care hospital (LTACH) patients to identify gut microbiota and clinical features associated with colonization by
resultsCase (n = 32) and control (n = 99) patients had distinct fecal microbiota communities, but neither microbiota diversity nor inherent clustering into community types distinguished case and control specimens. Comparison of differentially abundant operational taxonomic units (OTUs) revealed 1 OTU associated with case status in both calibration (n = 51) and validation (n = 80) subsamples that matched the canonical KPC-Kp strain ST258. Permutation analysis using the presence or absence of OTUs and hierarchical logistic regression identified 2 OTUs (belonging to genus
conclusionsWe identified microbiota and clinical features that distinguished KPC-Kp gut colonization in LTACH patients, a population particularly susceptible to KPC-Kp infection. These features may warrant further investigation as markers of risk for KPC-Kp colonization.
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Registered trials
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