ArticleBioMed research international2018
Curcumin Attenuates Testicular Injury in Rats with Streptozotocin-Induced Diabetes.
Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
- Chlorella vulgaris and Lactobacillus casei Combination Therapy Attenuates Testicular Endoplasmic Reticulum Stress and Dysfunction in a C57BL/6 Mouse Model of NAFLD.Probiotics and antimicrobial proteins · 2026Article
- Policosanol ameliorates testicular injury and improves steroidogenesis in diabetic hypercholesterolemic rats.Molecular biology reports · 2025Article
- Systemic impacts of diabetes on spermatogenesis and intervention strategies: multilayered mechanism analysis and cutting-edge therapeutic approaches.Reproductive biology and endocrinology : RB&E · 2025Review
- Article
- Antidiabetic Effects of Quercetin and Silk Sericin in Attenuating Dysregulation of Hepatic Gluconeogenesis in Diabetic Rats Through Potential Modulation of PI3K/Akt/FOXO1 Signaling: In Vivo and In Silico Studies.Journal of xenobiotics · 2025Article
- Enhancing the bioavailability and activity of natural antioxidants with nanobubbles and nanoparticles.Redox report : communications in free radical research · 2024Review
- 1-DNJ Alleviates Obesity-Induced Testicular Inflammation in Mice Model by Inhibiting IKKβ/ NF-kB Pathway.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Wharton's Jelly Mesenchymal Stem Cell Conditioned Medium Ameliorates Diabetes-Induced Testicular Damage and Sperm Abnormalities by Mitigating Oxidative Stress, Apoptosis, and Inflammation.Stem cells international · 2024Article
- Article
- Pharmacological Mechanisms and Clinical Applications of Curcumin: Update.Aging and disease · 2023Review
- Quercetin Ameliorates Testicular Damage in Zucker Diabetic Fatty Rats through Its Antioxidant, Anti-Inflammatory and Anti-Apoptotic Properties.International journal of molecular sciences · 2022Article
- Characterization of the structural, oxidative, and immunological features of testis tissue from Zucker diabetic fatty rats.Open life sciences · 2022Article
- The Effects of Separate and Combined Treatment of Male Rats with Type 2 Diabetes with Metformin and Orthosteric and Allosteric Agonists of Luteinizing Hormone Receptor on Steroidogenesis and Spermatogenesis.International journal of molecular sciences · 2021Article
- Protective effects ofVeterinary research forum : an international quarterly journal · 2021Article
- Article
- The Role of Selected Natural Biomolecules in Sperm Production and Functionality.Molecules (Basel, Switzerland) · 2021Review
- Ellagic acid improved diabetes mellitus-induced testicular damage and sperm abnormalities by activation of Nrf2.Saudi journal of biological sciences · 2021Article
- Protective effects of curcumin on chromatin quality, sperm parameters, and apoptosis following testicular torsion-detorsion in mice.Clinical and experimental reproductive medicine · 2021Article
- Therapeutic Potential of Polyphenols in the Management of Diabetic Neuropathy.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Black soybean tempeh and purple sweet potato improve sperm quality in streptozotocin-induced diabetic rats.Veterinary world · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative damage, inflammation, and apoptosis are the primary features of diabetic testicular damage. Curcumin protects against diabetic testicular injury, but the underlying mechanisms remain obscure. This study examined the effect of curcumin on type 2 diabetes mellitus- (T2DM-) induced testicular injury, oxidative stress, and apoptotic changes. T2DM rats were intraperitoneally injected with 40 mg/kg STZ after being fed a high-fat diet for 8 weeks. One week after STZ injection, 100 or 200 mg/kg curcumin was administered orally to the diabetic rats for 16 weeks. Histological changes in the testes were determined by HE staining. Serum testosterone was measured. Markers of superoxide levels, such as SOD activity and MDA content, and markers of cell death, including the expression of Bax, Bcl-2, and MAPK family members, were measured by molecular biology or immunohistochemical techniques. Degeneration and disruption of seminiferous tubule structure were observed in diabetic rats. Serum testosterone levels were markedly lower in diabetic rats than in control rats. Moreover, testicular apoptosis and Bax expression were much higher in diabetic rats than in control rats. Superoxide generation, the NADP
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