Evidence map›Paper›PMID 30151371›Full record

ArticleERJ open research2018

Understanding asthma phenotypes: the World Asthma Phenotypes (WASP) international collaboration.

Lucy Pembrey, Mauricio L Barreto, Jeroen Douwes, Philip Cooper, John Henderson, Harriet Mpairwe, Cristina Ardura-Garcia, Martha Chico, Collin Brooks, Alvaro A Cruz and 7 more

Abstract read
In one paragraph

Article in ERJ open research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  4. Review
  5. Gut microbiome signature and nasal lavage inflammatory markers in young people with asthma.The journal of allergy and clinical immunology. Global · 2024
    Article
  6. Article
  7. Article
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  10. Article
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  12. Article
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  15. Novel potential treatable traits in asthma: Where is the research taking us?The journal of allergy and clinical immunology. Global · 2022
    Review
  16. Review
  17. Article
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  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Lucy PembreyLondon School of Hygiene and Tropical Medicine, London, UK.
Mauricio L BarretoInstitute of Collective Health, Federal University of Bahia, Salvador, Brazil.
Jeroen DouwesCentre for Public Health Research, Massey University, Wellington, New Zealand.
Philip CooperSt George's University of London, London, UK.
John HendersonPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Harriet MpairweMedical Research Council (MRC)/Uganda Virus Research Institute (UVRI) Uganda Research Unit on AIDS, Entebbe, Uganda.
Cristina Ardura-GarciaFundacion Ecuatoriana Para Investigacion en Salud, Quito, Ecuador.
Martha ChicoFundacion Ecuatoriana Para Investigacion en Salud, Quito, Ecuador.
Collin BrooksCentre for Public Health Research, Massey University, Wellington, New Zealand.
Alvaro A CruzThe Programme for Control of Asthma and Allergic Rhinitis (ProAR), Federal University of Bahia, Salvador, Brazil.
Alison M ElliottMedical Research Council (MRC)/Uganda Virus Research Institute (UVRI) Uganda Research Unit on AIDS, Entebbe, Uganda.
Camila A FigueiredoInstitute of Collective Health, Federal University of Bahia, Salvador, Brazil.
Sinéad M LanganLondon School of Hygiene and Tropical Medicine, London, UK.
Beatrice NassangaMedical Research Council (MRC)/Uganda Virus Research Institute (UVRI) Uganda Research Unit on AIDS, Entebbe, Uganda.
Susan RingPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Laura RodriguesLondon School of Hygiene and Tropical Medicine, London, UK.
Neil PearceLondon School of Hygiene and Tropical Medicine, London, UK.

Funding

European Research Council 668954Medical Research Council G0401540Medical Research Council G9815508Medical Research Council MC_UU_00027/5Wellcome Trust
6 · The paper itself

Abstract

The World Asthma Phenotypes (WASP) study started in 2016 and has been conducted in five centres, in the UK, New Zealand, Brazil, Ecuador and Uganda. The objectives of this study are to combine detailed biomarker and clinical information in order to 1) better understand and characterise asthma phenotypes in high-income countries (HICs) and low and middle-income countries (LMICs), and in high and low prevalence centres; 2) compare phenotype characteristics, including clinical severity; 3) assess the risk factors for each phenotype; and 4) assess how the distribution of phenotypes differs between high prevalence and low prevalence centres. Here we present the rationale and protocol for the WASP study to enable other centres around the world to carry out similar analyses using a standardised protocol. Large collaborative and integrative studies like this are essential to further our understanding of asthma phenotypes. The findings of this study will help elucidate the aetiological mechanisms of asthma and might potentially identify new causes and guide the development of new treatments, thereby enabling better management and prevention of asthma in both HICs and LMICs.

Identifiers

PMID30151371
PMCPMC6104297

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.