ArticleJournal of gastrointestinal oncology2018
Trends and disparities in the utilization of hypofractionated neoadjuvant radiation therapy for rectal cancer in the United States.
Article in Journal of gastrointestinal oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Sequential short-course radiation therapy and chemotherapy in the neoadjuvant treatment of rectal adenocarcinoma.Radiation oncology (London, England) · 2019Trial
- Radiation Therapy Expenditures Through the First 8 Performance Periods of the Oncology Care Model at a Statewide Multispecialty Health System.International journal of radiation oncology, biology, physics · 2023Article
- Landmark Series on Disparities in Surgical Oncology: Melanoma.Annals of surgical oncology · 2021Review
- Breast, Prostate, and Rectal Cancer: Should 5-5-5 Be a New Standard of Care?International journal of radiation oncology, biology, physics · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeoadjuvant conventionally fractionated radiotherapy (CFRT) versus hypofractionated radiotherapy (HFRT) for rectal cancer (RC) is among the most controversial and debatable areas of radiotherapeutic management. This is the only known study evaluating the utilization of neoadjuvant HFRT for RC in the United States, and focuses on trends and health disparities.
methodsThe National Cancer Data Base was queried [2004-2015] for newly-diagnosed cT3-T4 N
resultsAltogether, 29,994 patients met study criteria: 29,724 (99%) were treated with CFRT, and 270 (1%) with HFRT. Temporally, utilization of HFRT rose significantly, from 0.2% in 2004 to 2.0% in 2015, with the steepest slope at most recent time periods. HFRT was more likely administered to older patients, those with more comorbidities, and node-positive disease (P<0.05 for all). There were racial differences, as African-Americans were independently less likely to receive HFRT (P=0.043). The two strongest predictors of HFRT administration (by odds ratio) were time period and therapy at academic centers (P<0.05 for all).
conclusionsAlthough HFRT is underutilized in the US, its use is rising and has increased nearly tenfold over the last decade. Disparities in HFRT delivery are emphasized, especially concerning disease-/patient-specific factors, socioeconomic status, and race. These data may serve as a benchmark for future investigation as well as for health disparities in the radiotherapeutic treatment of RC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.