Evidence map›Paper›PMID 30151088›Full record

ArticleMedChemComm2018

Nucleoside triphosphate cosubstrates control the substrate profile and efficiency of aminoglycoside 3'-

Selina Y L Holbrook, Matthew S Gentry, Oleg V Tsodikov, Sylvie Garneau-Tsodikova

Open access · bronzeAbstract read
In one paragraph

Article in MedChemComm, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Selina Y L HolbrookDepartment of Pharmaceutical Sciences , College of Pharmacy , University of Kentucky , Lexington , KY 40536-0596 , USA . Email: oleg.tsodikov@uky.edu ; Email: sylviegtsodikova@uky.edu ; ; Tel: +859 218 1686.
Matthew S GentryDepartment of Molecular and Cellular Biochemistry , College of Medicine , University of Kentucky , Lexington , KY 40536 , USA.
Oleg V TsodikovDepartment of Pharmaceutical Sciences , College of Pharmacy , University of Kentucky , Lexington , KY 40536-0596 , USA . Email: oleg.tsodikov@uky.edu ; Email: sylviegtsodikova@uky.edu ; ; Tel: +859 218 1686.ORCID 0000-0001-7094-4216
Sylvie Garneau-TsodikovaDepartment of Pharmaceutical Sciences , College of Pharmacy , University of Kentucky , Lexington , KY 40536-0596 , USA . Email: oleg.tsodikov@uky.edu ; Email: sylviegtsodikova@uky.edu ; ; Tel: +859 218 1686.ORCID 0000-0002-7961-5555
University of Kentucky · US

Funding

Suppressing glycogen storage with small molecule inhibitors as a therapeutic approach to Lafora DiseaseP01NS097197 · NINDS · UNIVERSITY OF KENTUCKY · PI GAO, TIANYAN · 2016 to 2021
$9.0M
Novel aminoglycoside adjuvants and stand-alone agents to combat tuberculosisR01AI090048 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARNEAU-TSODIKOVA, SYLVIE · 2011 to 2021
$4.4M
Regulation, Signaling, and Dynamics of Glucan PhosphatasesR01NS070899 · NINDS · UNIVERSITY OF KENTUCKY · PI GENTRY, MATTHEW S. · 2010 to 2019
$3.6M
NIAID NIH HHS R01 AI090048NINDS NIH HHS P01 NS097197NINDS NIH HHS R01 NS070899
6 · The paper itself

Abstract

Aminoglycosides (AGs) are broad-spectrum antibiotics that play an important role in the control and treatment of bacterial infections. Despite the great antibacterial potency of AGs, resistance to these antibiotics has limited their clinical applications. The AG 3'-

Identifiers

PMID30151088
PMCPMC6097461
OpenAlexW2884177694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.