Evidence map›Paper›PMID 30151030›Full record

ArticleNature physics2018

Geometric constraints during epithelial jamming.

Lior Atia, Dapeng Bi, Yasha Sharma, Jennifer A Mitchel, Bomi Gweon, Stephan Koehler, Stephen J DeCamp, Bo Lan, Jae Hun Kim, Rebecca Hirsch and 8 more

Abstract read
In one paragraph

Article in Nature physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed.

  1. Cell jamming transition is regulated by mitochondrial pyruvate transport and endocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  12. Scaling the glassy dynamics of active particles: Tunable fragility and reentrance.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Article
  14. A thermodynamic perspective on mammalian neural crest ingression.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Review
  16. Spatiotemporal distribution of the glycoprotein pherophorin II reveals stochastic geometry of the growing ECM ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Article

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Lior AtiaHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Dapeng BiNortheastern University, Department of Physics, Boston, Massachusetts 02115, USA.
Yasha SharmaHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Jennifer A MitchelHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Bomi GweonHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Stephan KoehlerHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Stephen J DeCampHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Bo LanHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Jae Hun KimHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Rebecca HirschHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Adrian F PegoraroHarvard University, School of Engineering and Applied Sciences, Cambridge, Massachusetts 02138, USA.
Kyu Ha LeeThe Forsyth Institute, Cambridge, Massachusetts 02142 USA.
Jacqueline R StarrThe Forsyth Institute, Cambridge, Massachusetts 02142 USA.
David A WeitzHarvard University, School of Engineering and Applied Sciences, Cambridge, Massachusetts 02138, USA.
Adam C MartinMassachusetts Institute of Technology, Department of Biology, Cambridge, Massachusetts 02142, USA.
Jin-Ah ParkHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
James P ButlerHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.
Jeffrey J FredbergHarvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
Training Program in Molecular and Integrative Physiological SciencesT32HL007118 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LU, QUAN · 1985 to 2025
$14.3M
Physics of collective cellular migration in lung health and diseaseP01HL120839 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2014 to 2018
$12.2M
Epithelial layer jamming in breast cancer cell migrationU01CA202123 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2015 to 2019
$3.4M
Mechanics of Monolayer MigrationR01HL107561 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2011 to 2015
$3.1M
NCATS NIH HHS UL1 TR001102NCI NIH HHS U01 CA202123NHLBI NIH HHS P01 HL120839NHLBI NIH HHS R01 HL107561NHLBI NIH HHS T32 HL007118
6 · The paper itself

Abstract

As an injury heals, an embryo develops, or a carcinoma spreads, epithelial cells systematically change their shape. In each of these processes cell shape is studied extensively whereas variability of shape from cell-to-cell is regarded most often as biological noise. But where do cell shape and its variability come from? Here we report that cell shape and shape variability are mutually constrained through a relationship that is purely geometrical. That relationship is shown to govern processes as diverse as maturation of the pseudostratified bronchial epithelial layer cultured from non-asthmatic or asthmatic donors, and formation of the ventral furrow in the

Identifiers

PMID30151030
PMCPMC6108541

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.