Evidence map›Paper›PMID 30150991›Full record

ReviewFrontiers in immunology2018

Natural Killer Cells: Development, Maturation, and Clinical Utilization.

Alex M Abel, Chao Yang, Monica S Thakar, Subramaniam Malarkannan

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 702 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
702citing papers in PubMed, 1 pooled it
34.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

702 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,094 citations in OpenAlex.

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  14. Cervical Cytokine Profile in High-Grade Squamous Intraepithelial Lesions.Cytopathology : official journal of the British Society for Clinical Cytology · 2026
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642 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alex M AbelLaboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, United States.
Chao YangLaboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, United States.
Monica S ThakarLaboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, United States.
Subramaniam MalarkannanLaboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, United States.
Versiti Blood Center of Wisconsin · USMedical College of Wisconsin · US

Funding

Molecular signature of inflammationR01CA179363 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI MALARKANNAN, SUBRAMANIAM · 2014 to 2018
$1.6M
Molecular mechanisms of signaling co-ordination in innate lymphocytesR01AI102893 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI MALARKANNAN, SUBRAMANIAM · 2013 to 2016
$1.5M
NCI NIH HHS R01 CA179363NIAID NIH HHS R01 AI102893
6 · The paper itself

Abstract

Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells do not express polymorphic clonotypic receptors and utilize inhibitory receptors (killer immunoglobulin-like receptor and Ly49) to develop, mature, and recognize "

Indexed as

Immunity, InnateAnimalsCell DifferentiationCytokinesHumansImmunologic SurveillanceImmunotherapyInterleukin Receptor Common gamma SubunitKiller Cells, NaturalNeoplasmsNK Cell Lectin-Like Receptor Subfamily AReceptors, KIRSignal TransductionTranslational Research, BiomedicalVirus DiseasesCytokinesInterleukin Receptor Common gamma SubunitNK Cell Lectin-Like Receptor Subfamily AReceptors, KIRdevelopmental stageseffector functionshumanmousenatural killer cells

Identifiers

PMID30150991
PMCPMC6099181
OpenAlexW2885605094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.