Evidence map›Paper›PMID 30150988›Full record

ReviewFrontiers in immunology2018

Synaptic Interactions in Germinal Centers.

Ilenia Papa, Carola G Vinuesa

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  14. TACI and endogenous APRIL in B cell maturation.Clinical immunology (Orlando, Fla.) · 2023
    Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ilenia PapaJohn Curtin School of Medical Research, Australian National University, Acton, ACT, Australia.
Carola G VinuesaJohn Curtin School of Medical Research, Australian National University, Acton, ACT, Australia.
Australian National University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The germinal center (GC) is a complex, highly dynamic microanatomical niche that allows the generation of high-affinity antibody-producing plasma cells and memory B cells. These cells constitute the basis of long-lived highly protective antibody responses. For affinity maturation to occur, B cells undergo multiple rounds of proliferation and mutation of the genes that encode the immunoglobulin V region followed by selection by specialized T cells called follicular helper T (T

Indexed as

AnimalsAntibody AffinityAutoantigensAutoimmunityB-LymphocytesCell CommunicationCytokinesElectrical SynapsesEpitopesGerminal CenterHumansImmunological SynapsesNeurotransmitter AgentsSignal TransductionT-Lymphocytes, Helper-InducerAutoantigensCytokinesEpitopesNeurotransmitter Agentsdense core granulesgerminal centergerminal centre B cellsimmunological synapseT follicular helper (TFH) cell

Identifiers

PMID30150988
PMCPMC6099157
OpenAlexW2887571512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.