Evidence map›Paper›PMID 30150944›Full record

ArticleFrontiers in psychiatry2018

From Default Mode Network to the Basal Configuration: Sex Differences in the Resting-State Brain Connectivity as a Function of Age and Their Clinical Correlates.

Sean D Conrin, Liang Zhan, Zachery D Morrissey, Mengqi Xing, Angus Forbes, Pauline Maki, Mohammed R Milad, Olusola Ajilore, Scott A Langenecker, Alex D Leow

Abstract read
In one paragraph

Article in Frontiers in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Sex differences in the functional topography of association networks in youth.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Spatio-Temporal Graph Convolution for Resting-State fMRI Analysis.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2020
    Article
  14. Review
  15. A GENERALIZED FRAMEWORK OF PATHLENGTH ASSOCIATED COMMUNITY ESTIMATION FOR BRAIN STRUCTURAL NETWORK.Proceedings. IEEE International Symposium on Biomedical Imaging · 2020
    Article
  16. Article
  17. Sex differences in development of functional connections in the face processing network.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sean D ConrinDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States.
Liang ZhanDepartment of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA, United States.
Zachery D MorrisseyDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States.
Mengqi XingDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States.
Angus ForbesDepartment of Computational Media, University of California, Santa Cruz, Santa Cruz, CA, United States.
Pauline MakiDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States.
Mohammed R MiladDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States.
Olusola AjiloreDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States.
Scott A LangeneckerDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States.
Alex D LeowDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States.

Funding

Highly-sensitive imaging markers for early detection of Alzheimer's Disease using multi-view connectomicsR21AG056782 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEOW, ALEX, THOMPSON, PAUL M · 2017 to 2018
$425k
NIA NIH HHS R21 AG056782
6 · The paper itself

Abstract

Connectomics is a framework that models brain structure and function interconnectivity as a network, rather than narrowly focusing on select regions-of-interest. MRI-derived connectomes can be structural, usually based on diffusion-weighted MR imaging, or functional, usually formed by examining fMRI blood-oxygen-level-dependent (BOLD) signal correlations. Recently, we developed a novel method for assessing the hierarchical modularity of functional brain networks-the probability associated community estimation (PACE). PACE uniquely permits a dual formulation, thus yielding equivalent connectome modular structure regardless of whether positive or negative edges are considered. This method was rigorously validated using the 1,000 functional connectomes project data set (F1000, RRID:SCR_005361) (1) and the Human Connectome Project (HCP, RRID:SCR_006942) (2, 3) and we reported novel sex differences in resting-state connectivity not previously reported. (4) This study further examines sex differences in regard to hierarchical modularity as a function of age and clinical correlates, with findings supporting a basal configuration framework as a more nuanced and dynamic way of conceptualizing the resting-state connectome that is modulated by both age and sex. Our results showed that differences in connectivity between men and women in the 22-25 age range were not significantly different. However, these same non-significant differences attained significance in both the 26-30 age group (

Indexed as

brain connectivitycommunity structuredefault-mode networkhuman connectome projectmodularityresting-state fMRIsex differences

Identifiers

PMID30150944
PMCPMC6100484

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.