ArticleFrontiers in integrative neuroscience2018
Distinct Dynamics of Striatal and Prefrontal Neural Activity During Temporal Discrimination.
Article in Frontiers in integrative neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Medium Spiny Neurons Mediate Timing Perception in Coordination with Prefrontal Neurons in Primates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Stable sequential dynamics in prefrontal cortex represents subjective estimation of time.eLife · 2024Article
- Using temperature to analyze the neural basis of a time-based decision.Nature neuroscience · 2023Article
- The neural bases for timing of durations.Nature reviews. Neuroscience · 2022Review
- Ramping activity in the striatum.Frontiers in computational neuroscience · 2022Article
- CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Temporal Learning Among Prefrontal and Striatal Ensembles.Cerebral cortex communications · 2020Article
- Believing in dopamine.Nature reviews. Neuroscience · 2019Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The frontal cortex-basal ganglia circuit plays an important role in interval timing. We examined neuronal discharges in the dorsomedial and dorsolateral striatum (DMS and DLS) in rats performing a temporal categorization task and compared them with previously recorded neuronal activity in the medial prefrontal cortex (mPFC). All three structures conveyed significant temporal information, but striatal neurons seldom showed the prolonged, full-interval spanning ramping activity frequently observed in the mPFC. Instead, the majority fired briefly during sample intervals. Also, the precision of neural time decoding became progressively worse with increasing time duration in the mPFC, but not in the striatum. With the caveat that mPFC and striatal units were recorded from different animals, our results suggest that the striatum and mPFC convey temporal information via distinct neural processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.