Evidence map›Paper›PMID 30150775›Full record

ArticleNature2018

The NORAD lncRNA assembles a topoisomerase complex critical for genome stability.

Mathias Munschauer, Celina T Nguyen, Klara Sirokman, Christina R Hartigan, Larson Hogstrom, Jesse M Engreitz, Jacob C Ulirsch, Charles P Fulco, Vidya Subramanian, Jenny Chen and 4 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 235 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
235citing papers in PubMed, 2 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

235 citing papers in PubMed, 2 syntheses or guidelines pooled it, 399 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. RNase MRP subunit composition and role in 40S ribosome biogenesis.Nature structural & molecular biology · 2026
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

175 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Mathias MunschauerBroad Institute of MIT and Harvard, Cambridge, MA, USA. mathias@broadinstitute.org.
Celina T NguyenBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Klara SirokmanBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Christina R HartiganBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Larson HogstromBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Jesse M EngreitzBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Jacob C UlirschBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Charles P FulcoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Vidya SubramanianBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Jenny ChenBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Monica SchenoneBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Mitchell GuttmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Steven A CarrBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Eric S LanderBroad Institute of MIT and Harvard, Cambridge, MA, USA. eric@broadinstitute.org.
Broad Institute · USBoston Children's Hospital · USCalifornia Institute of Technology · USHarvard–MIT Division of Health Sciences and Technology · US

Funding

Deciphering the function and mechanisms of lncRNA-mediated organization of nuclear compartmentsU01DA040612 · NIDA · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GUTTMAN, MITCHELL, RINN, JOHN LOUIS · 2015 to 2019
$4.1M
Novel tools to comprehensively map dynamic organization of RNA and DNA in higher-order nuclear structures within single cellsU01HL130007 · NHLBI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GUTTMAN, MITCHELL, ISMAGILOV, RUSTEM F · 2015 to 2019
$3.9M
Deciphering the mechanism of large ncRNA mediated regulation of cell stateDP5OD012190 · OD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GUTTMAN, MITCHELL · 2012 to 2016
$2.4M
NHLBI NIH HHS U01 HL130007NIDA NIH HHS U01 DA040612NIH HHS DP5 OD012190
6 · The paper itself

Abstract

The human genome contains thousands of long non-coding RNAs

Indexed as

Genomic InstabilityBinding SitesCell CycleCell Cycle ProteinsCell NucleusCell SurvivalChromosome SegregationDNA DamageDNA RepairDNA Repair EnzymesDNA ReplicationDNA Topoisomerases, Type IHeterogeneous-Nuclear RibonucleoproteinsHumansMass SpectrometryMultiprotein ComplexesALYREF protein, humanCDC5L protein, humanCell Cycle ProteinsDNA Repair EnzymesDNA Topoisomerases, Type IHeterogeneous-Nuclear RibonucleoproteinsMultiprotein ComplexesNuclear ProteinsPRPF19 protein, humanRBMX protein, humanRibonucleoproteinsRNA-Binding ProteinsRNA, Long NoncodingRNA Splicing FactorsTranscription Factors

Identifiers

PMID30150775
OpenAlexW2888500336

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.