Evidence map›Paper›PMID 30150769›Full record

ArticleScientific reports2018

Focused Ultrasound-Induced Blood-Brain Barrier Opening Enhances GSK-3 Inhibitor Delivery for Amyloid-Beta Plaque Reduction.

Po-Hung Hsu, Ya-Tin Lin, Yi-Hsiu Chung, Kun-Ju Lin, Liang-Yo Yang, Tzu-Chen Yen, Hao-Li Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  17. Stable Cavitation Interferes with AβJournal of chemical information and modeling · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Po-Hung HsuCenter for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, Taoyuan, Taiwan.ORCID 0000-0002-2941-4712
Ya-Tin LinGraduate Institute of Biomedical Sciences, Department of Physiology and Pharmacology, Chang Gung University, Taoyuan, Taiwan.
Yi-Hsiu ChungCenter for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Kun-Ju LinDepartment of Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Liang-Yo YangDepartment of Physiology, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Tzu-Chen YenCenter for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Hao-Li LiuDepartment of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan. haoliliu@mail.cgu.edu.tw.ORCID 0000-0003-1541-1227

Funding

Chang Gung Memorial Hospital, Linkou (Linkou Chang Gung Memorial Hospital) CMRPD2D0111-13Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) 105-2221-E-182-022
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disease that is the leading cause of age-related dementia. Currently, therapeutic agent delivery to the CNS is a valued approach for AD therapy. Unfortunately, the CNS penetration is greatly hampered by the blood-brain barrier (BBB). Focused-ultrasound (FUS) has been demonstrated to temporally open the BBB, thus promoting therapeutic agent delivery to the CNS. Recently, the BBB opening procedure was further reported to clear the deposited Aβ plaque due to microglia activation. In this study, we aimed to evaluate whether the use of FUS-induced BBB opening to enhance GSK-3 inhibitor delivery, which would bring additive effect of Aβ plaque clearance by FUS with the reduction of Aβ plaque synthesis by GSK-3 inhibitor in an AD mice model. FUS-induced BBB opening on APPswe/PSEN1-dE9 transgenic mice was performed unilaterally, with the contralateral hemisphere serving as a reference. GSK-3 level was confirmed by immunohistochemistry (IHC) and autoradiography (ARG) was also conducted to quantitatively confirm the Aβ plaque reduction. Results from IHC showed GSK-3 inhibitor effectively reduced GSK-3 activity up to 61.3% with the addition of FUS-BBB opening and confirming the proposed therapeutic route. ARG also showed significant Aβ-plaque reduction up to 31.5%. This study reveals the therapeutic potentials of ultrasound to AD treatment, and may provide a useful strategy for neurodegenerative disease treatment.

Indexed as

Ultrasonic WavesAmyloid beta-PeptidesAnimalsBiomarkersBlood-Brain BarrierBrainEnzyme InhibitorsGlycogen Synthase Kinase 3ImmunohistochemistryMaleMiceMice, TransgenicPlaque, AmyloidProtein AggregatesProtein Aggregation, PathologicalProtein BindingAmyloid beta-PeptidesBiomarkersEnzyme InhibitorsGlycogen Synthase Kinase 3N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)ureaProtein AggregatesThiazolesUrea

Identifiers

PMID30150769
PMCPMC6110796

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.