Evidence map›Paper›PMID 30150731›Full record

ArticleScientific reports2018

Removal of choroidal vasculature using concurrently applied ultrasound bursts and nanosecond laser pulses.

Haonan Zhang, Xinyi Xie, Jia Li, Yu Qin, Wei Zhang, Qian Cheng, Songtao Yuan, Qinghuai Liu, Yannis M Paulus, Xueding Wang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Ultrasound-assisted laser therapy for selective removal of melanoma cells.Experimental biology and medicine (Maywood, N.J.) · 2024
    Article
  3. Cutaneous Hypervascularization Treatment Using Photo-Mediated Ultrasound Therapy.JID innovations : skin science from molecules to population health · 2023
    Article
  4. Article
  5. A review on photo-mediated ultrasound therapy.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Photo-mediated Ultrasound Therapy to Treat Retinal Neovascularization.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020
    Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Haonan ZhangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Xinyi XieDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Jia LiDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Yu QinDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Wei ZhangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Qian ChengInstitute of Acoustics, School of Physics Science and Engineering, Tongji University, Shanghai, China.
Songtao YuanDepartment of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China.ORCID 0000-0001-9212-0664
Qinghuai LiuDepartment of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China.ORCID 0000-0003-4257-8970
Yannis M PaulusDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. ypaulus@med.umich.edu.
Xueding WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. xdwang@umich.edu.
Xinmai YangInstitute for Bioengineering Research and Department of Mechanical Engineering, University of Kansas, Lawrence, KS, USA. xmyang@ku.edu.ORCID 0000-0001-8120-6593
Tongji University · CNUniversity of Michigan · USJiangsu Province Hospital · CNUniversity of Kansas · US

Funding

VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Peter F Hitchcock · 1987 to 2026
$17.6M
Michigan Vision Clinician Scientist Development ProgramK12EY022299 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Abigail Fahim, DAVID N ZACKS · 2013 to 2026
$6.3M
Precisely removing microvessels by photo-mediated ultrasound therapyR01EY029489 · NEI · UNIVERSITY OF KANSAS LAWRENCE · PI YANG, XINMAI · 2018 to 2021
$1.8M
NEI NIH HHS K12 EY022299NEI NIH HHS P30 EY007003NEI NIH HHS R01 EY029489
6 · The paper itself

Abstract

Pathologic microvasculature plays a crucial role in innumerable diseases causing death and major organ impairment. A major clinical challenge is the development of selective therapies to remove these diseased microvessels without damaging surrounding tissue. This report describes our development of novel photo-mediated ultrasound therapy (PUT) technology for precisely removing choroidal blood vessels in the eye. PUT selectively removes microvessels by concurrently applying nanosecond laser pulses with ultrasound bursts. In PUT experiments on rabbit eyes in vivo, we applied 55-75 mJ/cm

Indexed as

LasersNeovascularization, PathologicUltrasonic WavesAnimalsChoroidFluorescein AngiographyLaser TherapyOphthalmoscopesRabbitsUltrasonic Therapy

Identifiers

PMID30150731
PMCPMC6110758
OpenAlexW2888435800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.