ArticleNature medicine2018
Regional variation limits applications of healthy gut microbiome reference ranges and disease models.
Erratum issued 3 registry-linked trialsAbstract read
In one paragraph
Article in Nature medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 521 papers, 12 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
521citing papers in PubMed, 12 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Microbiome/Peptidome-based Model for Non-invasive Detection of High-risk Gastroesophageal Varices in Compensated Cirrhosis (CHESS1901/APPHA1901): A Prospective Multicenter Study
The Association of Gut Microbiota and Spermatogenic Dysfunction
A Multicentre Study on Features of the Gut Microbiota of Patients With Critical Chronic Diseases in China
Who cites it
521 citing papers in PubMed, 12 syntheses or guidelines pooled it.
- Clinical value of probiotics as adjunctive therapy for diabetic nephropathy: a meta-analysis and trial sequential analysis.Frontiers in nutrition · 2026Pooled it
- Probiotic Supplementation and Bone Health Parameters in Adults: A Systematic Review and Meta-Analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- Associations between prevalent unhealthy lifestyles and the gut microbiota: a comprehensive multi-database bibliometric analysis of pathogenic mechanisms and clinical trajectories.Frontiers in medicine · 2026Pooled it
- Cross-cohort analysis identifies shared gut microbial signatures and validates microbial risk scores for colorectal cancer.Journal of translational medicine · 2025Pooled it
- A scoping review of the health effects of fermented foods in specific human populations and their potential role in precision nutrition: current knowledge and gaps.Frontiers in nutrition · 2025Pooled it
- Gut microbiota and type 2 diabetes associations: a meta-analysis of 16S studies and their methodological challenges.Frontiers in microbiomes · 2025Pooled it
- Integrative metagenomic analysis reveals distinct gut microbial signatures related to obesity.BMC microbiology · 2024Pooled it
- A gut microbial signature for combination immune checkpoint blockade across cancer types.Nature medicine · 2024Pooled it
- Association between primary Sjögren's syndrome and gut microbiota disruption: a systematic review and meta-analysis.Clinical rheumatology · 2024Pooled it
- Causal relationship between gut microbiota and polycystic ovary syndrome: a literature review and Mendelian randomization study.Frontiers in endocrinology · 2024Pooled it
- Early-life exposure to the Great Chinese Famine and gut microbiome disruption across adulthood for type 2 diabetes: three population-based cohort studies.BMC medicine · 2023Pooled it
- Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy.Nature reviews. Clinical oncology · 2023Pooled it
- Trial
- Review
- Identifying low-quality features and suboptimal models to enhance phenotype prediction.Patterns (New York, N.Y.) · 2026Article
- Comparative analysis of gut microbiota in incident and prevalent peritoneal dialysis patients with peritoneal fibrosis, correlations with peritoneal equilibration test data in the peritoneal fibrosis cohort.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026Article
- Microbiome-pancreatic cancer crosstalk: From tumor biology to therapeutic intervention.iMetaOmics · 2026Review
- Microbial Signals in Cancer: Dissecting Host-Microbiota-Tumor Interactions and Potential Therapeutic Strategy.MedComm · 2026Review
- Microbiome and aging: Trajectories of microbiome age across human ecosystems and their systemic effects.iMeta · 2026Review
- Maternal and infant gut microbiome.iMeta · 2026Review
461 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
24 authors.
Yan He *Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Wei Wu *Department of Environmental Health, School of Public Health, Southern Medical University, Guangzhou, China.
Hui-Min Zheng *Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Pan Li *Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Daniel McDonaldDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.
Hua-Fang ShengDivision of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Mu-Xuan ChenDivision of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Zi-Hui ChenGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
Gui-Yuan JiGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
Zhong-Dai-Xi ZhengDepartment of Environmental Health, School of Public Health, Southern Medical University, Guangzhou, China.
Prabhakar MujagondGut Infection and Inflammation Biology Lab, UNESCO-Regional Center for Biotechnology, NCR Biotech Science Cluster, Faridabad, India.
Xiao-Jiao ChenDivision of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Zu-Hua RongDivision of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Peng ChenDepartment of Pathophysiology, Southern Medical University, Guangzhou, China.
Li-Yi LyuShenzhen Fun-Poo Biotech Co., Ltd., Shenzhen, China.
Xian WangShenzhen Fun-Poo Biotech Co., Ltd., Shenzhen, China.
Chong-Bin WuShenzhen Fun-Poo Biotech Co., Ltd., Shenzhen, China.
Nan YuDivision of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Yan-Jun XuGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
Jia YinDepartment of Neurology, NanFang Hospital, Southern Medical University, Guangzhou, China.
Jeroen RaesDepartment of Microbiology and Immunology, KU Leuven-University of Leuven, Leuven, Belgium.
Rob KnightDepartment of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0975-9019
Wen-Jun MaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China. mawj@gdiph.org.cn.
Hong-Wei ZhouDivision of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China. biodegradation@gmail.com.ORCID http://orcid.org/0000-0003-2472-8541
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dysbiosis, departure of the gut microbiome from a healthy state, has been suggested to be a powerful biomarker of disease incidence and progression
Indexed as
PhylogeographyChinaFemaleGastrointestinal MicrobiomeHost-Pathogen InteractionsHumansMaleMetabolic DiseasesPrognosis
Identifiers
PMID
30150716What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.