Evidence map›Paper›PMID 30150662›Full record

ArticleNature neuroscience2018

Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type.

Eszter Boldog, Trygve E Bakken, Rebecca D Hodge, Mark Novotny, Brian D Aevermann, Judith Baka, Sándor Bordé, Jennie L Close, Francisco Diez-Fuertes, Song-Lin Ding and 24 more

Open access · bronzeAbstract read
In one paragraph

Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 317 citations in OpenAlex.

  1. Trial
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  10. Sex and life experience shape locus coeruleus pretangle tau pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  14. The Freiburg framework for multimodalFrontiers in synaptic neuroscience · 2026
    Article
  15. Modeling pediatric brain tumors with human stem cells.Frontiers in cellular neuroscience · 2026
    Review
  16. Article
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  20. Review

109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 5 institutions in 2 countries.

Eszter BoldogMTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary.
Trygve E BakkenAllen Institute for Brain Science, Seattle, WA, USA.
Rebecca D HodgeAllen Institute for Brain Science, Seattle, WA, USA.
Mark NovotnyJ. Craig Venter Institute, La Jolla, CA, USA.
Brian D AevermannJ. Craig Venter Institute, La Jolla, CA, USA.
Judith BakaMTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary.
Sándor BordéMTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary.
Jennie L CloseAllen Institute for Brain Science, Seattle, WA, USA.
Francisco Diez-FuertesJ. Craig Venter Institute, La Jolla, CA, USA.
Song-Lin DingAllen Institute for Brain Science, Seattle, WA, USA.
Nóra FaragóMTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary.
Ágnes K KocsisMTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary.
Balázs KovácsMTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary.
Zoe MaltzerAllen Institute for Brain Science, Seattle, WA, USA.
Jamison M McCorrisonJ. Craig Venter Institute, La Jolla, CA, USA.
Jeremy A MillerAllen Institute for Brain Science, Seattle, WA, USA.
Gábor MolnárMTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary.
Gáspár OláhMTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary.
Attila OzsvárMTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary.
Márton RózsaMTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary.
Soraya I ShehataAllen Institute for Brain Science, Seattle, WA, USA.
Kimberly A SmithAllen Institute for Brain Science, Seattle, WA, USA.
Susan M SunkinAllen Institute for Brain Science, Seattle, WA, USA.
Danny N TranJ. Craig Venter Institute, La Jolla, CA, USA.
Pratap VenepallyJ. Craig Venter Institute, La Jolla, CA, USA.
Abby WallAllen Institute for Brain Science, Seattle, WA, USA.
László G PuskásLaboratory of Functional Genomics, Department of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary.
Pál BarzóIllumina, Inc., San Diego, CA, USA.
Frank J SteemersDepartment of Neurosurgery, University of Szeged, Szeged, Hungary.
Nicholas J SchorkJ. Craig Venter Institute, La Jolla, CA, USA.
Richard H ScheuermannJ. Craig Venter Institute, La Jolla, CA, USA.
Roger S LaskenJ. Craig Venter Institute, La Jolla, CA, USA.
Ed S LeinAllen Institute for Brain Science, Seattle, WA, USA. EdL@alleninstitute.org.ORCID http://orcid.org/0000-0001-9012-6552
Gábor TamásMTA-SZTE Research Group for Cortical Microcircuits, Department of Anatomy, Physiology and Neuroscience, University of Szeged, Szeged, Hungary. gtamas@bio.u-szeged.hu.ORCID http://orcid.org/0000-0002-7905-6001
University of Szeged · HUAllen Institute for Brain Science · USJ. Craig Venter Institute · USHungarian Academy of Sciences · HUIllumina (United States) · US

Funding

A multimodal atlas of human brain cell typesU01MH114812 · NIMH · ALLEN INSTITUTE · PI LEIN, ED · 2017 to 2021
$19.2M
European Research Council 269065NIMH NIH HHS U01 MH114812
6 · The paper itself

Abstract

We describe convergent evidence from transcriptomics, morphology, and physiology for a specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus RNA sequencing, we identify ten GABAergic interneuron subtypes with combinatorial gene signatures in human cortical layer 1 and characterize a group of human interneurons with anatomical features never described in rodents, having large 'rosehip'-like axonal boutons and compact arborization. These rosehip cells show an immunohistochemical profile (GAD1

Indexed as

TranscriptomeAdultAgedAxonsCerebral CortexDendritic SpinesGABAergic NeuronsGap JunctionsGene LibraryHumansMalePolymerase Chain ReactionPresynaptic TerminalsPyramidal CellsRNASequence Analysis, RNARNA

Identifiers

PMID30150662
PMCPMC6130849
OpenAlexW2767443671

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.