Evidence map›Paper›PMID 30150634›Full record

ArticleNature nanotechnology2018

Nucleic acid hybridization on an electrically reconfigurable network of gold-coated magnetic nanoparticles enables microRNA detection in blood.

Roya Tavallaie, Joshua McCarroll, Marion Le Grand, Nicholas Ariotti, Wolfgang Schuhmann, Eric Bakker, Richard David Tilley, David Brynn Hibbert, Maria Kavallaris, John Justin Gooding

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Nature nanotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 297 citations in OpenAlex.

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  18. Signal-Amplified Nanobiosensors for Virus Detection Using Advanced Nanomaterials.Advances in biochemical engineering/biotechnology · 2024
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Roya TavallaieSchool of Chemistry, University of New South Wales Sydney, Sydney, New South Wales, Australia.
Joshua McCarrollAustralian Centre for NanoMedicine, University of New South Wales Sydney, Sydney, New South Wales, Australia.
Marion Le GrandTumour Biology and Targeting Program, Lowy Cancer Research Centre, Children's Cancer Institute, University of New South Wales Sydney, Sydney, New South Wales, Australia.
Nicholas AriottiElectron Microscope Unit, Mark Wainwright Analytical Centre, University of New I South Wales Sydney, Sydney, New South Wales, Australia.
Wolfgang SchuhmannAnalytical Chemistry - Center for Electrochemical Sciences (CES), Ruhr-Universität Bochum, Bochum, Germany.ORCID http://orcid.org/0000-0003-2916-5223
Eric BakkerDepartment of Inorganic and Analytical Chemistry, University of Geneva, Geneva, Switzerland.
Richard David TilleySchool of Chemistry, University of New South Wales Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-2097-063X
David Brynn HibbertSchool of Chemistry, University of New South Wales Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0001-9210-2941
Maria KavallarisAustralian Centre for NanoMedicine, University of New South Wales Sydney, Sydney, New South Wales, Australia.
John Justin GoodingSchool of Chemistry, University of New South Wales Sydney, Sydney, New South Wales, Australia. justin.gooding@unsw.edu.au.
UNSW Sydney · AUCancer Institute of New South Wales · AURuhr University Bochum · DEUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is intense interest in quantifying the levels of microRNA because of its importance as a blood-borne biomarker. The challenge has been to develop methods that can monitor microRNA expression both over broad concentration ranges and in ultralow amounts directly in a patient's blood. Here, we show that, through electric-field-induced reconfiguration of a network of gold-coated magnetic nanoparticles modified by probe DNA (DNA-Au@MNPs), it is possible to create a highly sensitive sensor for direct analysis of nucleic acids in samples as complex as whole blood. The sensor is the first to be able to detect concentrations of microRNA from 10 aM to 1 nM in unprocessed blood samples. It can distinguish small variations in microRNA concentrations in blood samples of mice with growing tumours. The ultrasensitive and direct detection of microRNA using an electrically reconfigurable DNA-Au@MNPs network makes the reported device a promising tool for cancer diagnostics.

Indexed as

Neoplasms, ExperimentalA549 CellsAnimalsCoated Materials, BiocompatibleDNA ProbesGoldHumansMagnetite NanoparticlesMiceMice, Inbred BALB CMice, NudeMicroRNAsNucleic Acid HybridizationRNA, NeoplasmCoated Materials, BiocompatibleDNA ProbesGoldMagnetite NanoparticlesMicroRNAsRNA, Neoplasm

Identifiers

PMID30150634
OpenAlexW2888543617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.