Evidence map›Paper›PMID 30150463›Full record

ArticleAntimicrobial agents and chemotherapy2018

Caspofungin Modulates Ryanodine Receptor-Mediated Calcium Release in Human Cardiac Myocytes.

Christian Koch, Jennifer Jersch, Emmanuel Schneck, Fabian Edinger, Hagen Maxeiner, Florian Uhle, Markus A Weigand, Melanie Markmann, Michael Sander, Michael Henrich

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Caspofungin induces the release of CaScientific reports · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Christian KochDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany christian.koch@chiru.med.uni-giessen.de.
Jennifer JerschDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany.
Emmanuel SchneckDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany.
Fabian EdingerDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany.
Hagen MaxeinerDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany.
Florian UhleDepartment of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany.
Markus A WeigandDepartment of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany.
Melanie MarkmannDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany.
Michael SanderDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital of Giessen and Marburg, Giessen, Germany.
Michael HenrichDepartment of Anesthesiology, St. Vincentius Clinics, Karlsruhe, Germany.
Universitätsklinikum Gießen und Marburg · DEUniversity Hospital Heidelberg · DESt. Vincentius-Kliniken · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies showed that critically ill patients might be at risk for hemodynamic impairment during caspofungin (CAS) therapy. The aim of our present study was to examine the mechanisms behind CAS-induced cardiac alterations. We revealed a dose-dependent increase in intracellular Ca

Indexed as

AnimalsCaffeineCalciumCalcium SignalingCaspofunginHumansMyocytes, CardiacRatsRyanodine Receptor Calcium Release ChannelCaffeineCalciumCaspofunginRyanodine Receptor Calcium Release Channeladverse drug reactionantifungal agentscardiac outputcardiac toxicity

Identifiers

PMID30150463
PMCPMC6201063
OpenAlexW2888033274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.