Evidence map›Paper›PMID 30150418›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.

Iuliana V Ene, Rhys A Farrer, Matthew P Hirakawa, Kennedy Agwamba, Christina A Cuomo, Richard J Bennett

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed.

  1. Article
  2. Observational
  3. Review
  4. Article
  5. Paralogs of thebioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Adaptive Laboratory Evolution of Pichia pastoris by Serial Batch Cultivation.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  11. Article
  12. Article
  13. Computational Approaches for Discovering Virulence Factors inJournal of fungi (Basel, Switzerland) · 2025
    Review
  14. Article
  15. bioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Iuliana V EneDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912.
Rhys A FarrerInfectious Disease and Microbiome Program, The Broad Institute of MIT and Harvard, Cambridge, MA 02142.
Matthew P HirakawaDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912.
Kennedy AgwambaInfectious Disease and Microbiome Program, The Broad Institute of MIT and Harvard, Cambridge, MA 02142.
Christina A CuomoInfectious Disease and Microbiome Program, The Broad Institute of MIT and Harvard, Cambridge, MA 02142.ORCID 0000-0002-5778-960X
Richard J BennettDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912; Richard_Bennett@brown.edu.

Funding

Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI NEAFSEY, DANIEL E · 2014 to 2024
$66.5M
Transcriptional Regulation of C. albicans Cell Fate and Host InteractionsR01AI081704 · NIAID · BROWN UNIVERSITY · PI Richard John Bennett · 2010 to 2026
$6.4M
Development of Quantitative Genetics Approaches in Candida albicansR21AI122011 · NIAID · BROWN UNIVERSITY · PI BENNETT, RICHARD JOHN · 2016 to 2017
$450k
Genotypic plasticity and parasex in Candida albicansR21AI112363 · NIAID · BROWN UNIVERSITY · PI BENNETT, RICHARD JOHN · 2014 to 2015
$447k
Defining the Roles of Perseverance and Heteroresistance in Persistent Human Fungal InfectionsR21AI139592 · NIAID · BROWN UNIVERSITY · PI BENNETT, RICHARD JOHN · 2018 to 2019
$447k
Parasexual Genetics and Host Adaptation in Candida Fungal PathogensF31DE023726 · NIDCR · BROWN UNIVERSITY · PI HIRAKAWA, MATTHEW · 2014 to 2016
$132k
NIAID NIH HHS HHSN272200900018CNIAID NIH HHS R01 AI081704NIAID NIH HHS R21 AI112363NIAID NIH HHS R21 AI122011NIAID NIH HHS R21 AI139592NIAID NIH HHS U19 AI110818NIDCR NIH HHS F31 DE023726Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DiploidyEvolution, MolecularMutationCandida albicansCandidiasisChromosomes, FungalGenome, FungalHeterozygoteHumansLoss of HeterozygositySelection, GeneticaneuploidyCandida albicansdiploid speciesLOHmicroevolution

Identifiers

PMID30150418
PMCPMC6140516

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.