ArticleProceedings of the National Academy of Sciences of the United States of America2018
Multivalent, multiflavored droplets by design.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Cooperativity, entropy, and effective concentration in DNA origami self-replication.Science advances · 2026Article
- Design principles, growth laws, and competition of minimal autocatalysts.Communications chemistry · 2024Article
- Emergent dynamics due to chemo-hydrodynamic self-interactions in active polymers.Nature communications · 2024Article
- A coarse-grained simulation model for colloidal self-assemblySoft matter · 2023Article
- The Role of Receptor Uniformity in Multivalent Binding.JACS Au · 2023Article
- Programming Aggregate States of DNA Nanorods with Sub-10 nm Hydrophobic Patterns for Tunable Cell Entry.JACS Au · 2023Article
- Article
- Self-Assembly of DNA-Grafted Colloids: A Review of Challenges.Micromachines · 2022Review
- Direct visualization of floppy two-dimensional DNA origami using cryogenic electron microscopy.iScience · 2022Article
- DNA self-organization controls valence in programmable colloid design.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Dynamic self-assembly of compartmentalized DNA nanotubes.Nature communications · 2021Article
- Colloidal metallurgy.Nature chemistry · 2021Article
- Photo-printing of faceted DNA patchy particles.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nature self-assembles functional materials by programming flexible linear arrangements of molecules and then folding them to make 2D and 3D objects. To understand and emulate this process, we have made emulsion droplets with specific recognition and controlled valence. Uniquely monovalent droplets form dimers: divalent lead to polymer-like chains, trivalent allow for branching, and programmed mixtures of different valences enable a variety of designed architectures and the ability to subsequently close and open structures. Our functional building blocks are a hybrid of micrometer-scale emulsion droplets and nanoscale DNA origami technologies. Functional DNA origami rafts are first added to droplets and then herded into a patch using specifically designated "shepherding" rafts. Additional patches with the same or different specificities can be formed on the same droplet, programming multiflavored, multivalence droplets. The mobile patch can bind to a patch on another droplet containing complementary functional rafts, leading to primary structure formation. Further binding of nonneighbor droplets can produce secondary structures, a third step in hierarchical self-assembly. The use of mobile patches rather than uniform DNA coverage has the advantage of valence control at the expense of slow kinetics. Droplets with controlled flavors and valences enable a host of different material and device architectures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.