ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
A Brain-Heart Biomarker for Epileptogenesis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Observational
- Article
- Tissue Oxygenation Dynamics During Seizure to Spreading Depolarization in Rat Brain.bioRxiv : the preprint server for biology · 2025Article
- Causal relationships involving brain imaging-derived phenotypes based on UKB imaging cohort: a review of Mendelian randomization studies.Frontiers in neuroscience · 2024Review
- Impaired brain-heart axis in focal epilepsy: Alterations in information flow and implications for seizure dynamics.Network neuroscience (Cambridge, Mass.) · 2024Article
- Heart-brain axis: Association of congenital heart abnormality and brain diseases.Frontiers in cardiovascular medicine · 2023Review
- Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap.Nature reviews. Neurology · 2021Review
- Epileptic seizures.Discoveries (Craiova, Romania) · 2020Review
- Quantifying epileptogenesis in rats with spontaneous and responsive brain state dynamics.Brain communications · 2020Article
- Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models.Epilepsy currentsArticle
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Postinjury epilepsy is an potentially preventable sequela in as many as 20% of patients with brain insults. For these cases biomarkers of epileptogenesis are critical to facilitate identification of patients at high-risk of developing epilepsy and to introduce effective anti-epileptogenic interventions. Here, we demonstrate that delayed brain-heart coincidences serve as a reliable biomarker. In a murine model of post-infection acquired epilepsy, we used long-term simultaneous measurements of the brain activity via electroencephalography and autonomic cardiac activity via electrocardiography, in male mice, to quantitatively track brain-heart interactions during epileptogenesis. We find that abnormal cortical discharges precede abnormal fluctuations in the cardiac rhythm at the resolution of single beat-to-beat intervals. The delayed brain-heart coincidence is detectable as early as the onset of chronic measurements, 2-14 weeks before the first seizure, only in animals that become epileptic, and increases during epileptogenesis. Therefore, delayed brain-heart coincidence serves as a biomarker of epileptogenesis and could be used for phenotyping, diagnostic, and therapeutic purposes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.