ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
A Functional riboSNitch in the 3' Untranslated Region of
Open access · bronzeAbstract read
In one paragraph
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Painful physical symptoms and antidepressant treatment outcome in depression: a systematic review and meta-analysis.Molecular psychiatry · 2024Pooled it
- Mapping the research landscape of microRNAs in pain: a comprehensive bibliometric analysis.Frontiers in molecular neuroscience · 2024Pooled it
- Sex-specific molecular signatures in persistent pain after whiplash injury: an exploratory analysis.Pain reports · 2026Article
- Transcriptome of the human C2 dorsal root ganglia in C1-2 arthrodesis surgery: insight for neck pain.Brain : a journal of neurology · 2026Article
- Silent regulators of trauma: the microRNA blueprint underlying post-traumatic stress disorder biology.Environmental epigenetics · 2026Review
- Analgesia through FKBP51 inhibition at disease onset confers lasting relief from sensory and emotional chronic pain symptoms.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Modeling Pain Without Injury: Inherited Rodent Models as Mechanistic Windows into Chronic Pain.Function (Oxford, England) · 2025Review
- Sex differences in the transition to chronic pain.The Journal of clinical investigation · 2025Review
- VariantFoldRNA: a flexible, containerized, and scalable pipeline for genome-wide riboSNitch prediction.NAR genomics and bioinformatics · 2025Article
- The role of secondary structures in the functioning of 3' untranslated regions of mRNA: A review of functions of 3' UTRs' secondary structures and hypothetical involvement of secondary structures in cytoplasmic polyadenylation in Drosophila.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Review
- Causes, functions, and therapeutic possibilities of RNA secondary structure ensembles and alternative states.Cell chemical biology · 2024Review
- CpG Methylation Levels in HPA Axis Genes Predict Chronic Pain Outcomes Following Trauma Exposure.The journal of pain · 2023Article
- Article
- The Biology of Stress Intolerance in Patients with Chronic Pain-State of the Art and Future Directions.Journal of clinical medicine · 2023Review
- The Role of miRNAs in Neuropathic Pain.Biomedicines · 2023Review
- Evaluating Associations between Average Pain Intensity and Genetic Variation in People with Sickle Cell Disease: An Exploratory Study.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2023Article
- The association of FKBP5 polymorphisms with the severity of depressive disorder in patients with methamphetamine use disorders.Frontiers in psychiatry · 2023Article
- Article
- Disease-associated human genetic variation through the lens of precursor and mature RNA structure.Human genetics · 2022Review
- Duration of Reduction in Enduring Stress-Induced Hyperalgesia Via FKBP51 Inhibition Depends on Timing of Administration Relative to Traumatic Stress Exposure.The journal of pain · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 10 institutions in 3 countries.
Sarah D LinnstaedtInstitute for Trauma Recovery, sarah_linnstaedt@med.unc.edu.ORCID 0000-0001-5295-7072
Kyle D RikerInstitute for Trauma Recovery.ORCID 0000-0003-4788-8687
Cathleen A RueckeisInstitute for Trauma Recovery.ORCID 0000-0002-4032-6289
Katrina M KutchkoDepartment of Biology, The University of North Carolina, Chapel Hill, North Carolina 27599.
Lela LackeyDepartment of Biology, The University of North Carolina, Chapel Hill, North Carolina 27599.
Kathleen R McCarthyInstitute for Trauma Recovery.
Yi-Hsuan TsaiLineberger Comprehensive Cancer Center and Department of Genetics, The University of North Carolina, Chapel Hill, North Carolina 27514.ORCID 0000-0003-2107-4300
Joel S ParkerLineberger Comprehensive Cancer Center and Department of Genetics, The University of North Carolina, Chapel Hill, North Carolina 27514.
Michael C KurzDepartment of Emergency Medicine, University of Alabama School of Medicine, Birmingham, Alabama 35233.
Phyllis L HendryDepartment of Emergency Medicine, University of Florida College of Medicine, Jacksonville, Florida 32209.
Christopher LewandowskiDepartment of Emergency Medicine, Henry Ford Hospital, Detroit, Michigan 48202.
Elizabeth DatnerDepartment of Emergency Medicine, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141.
Claire PearsonDepartment of Emergency Medicine, Detroit Receiving, Detroit, Michigan 48201.ORCID 0000-0003-3810-8482
Brian O'NeilDepartment of Emergency Medicine.
Robert DomeierDepartment of Emergency Medicine, St. Joseph Mercy Health System, Ypsilanti, Michigan 48197, and.ORCID 0000-0002-4990-9165
Sangeeta KaushikDepartment of Emergency Medicine, MedStar Washington Hospital Center, Washington, DC 20010.
Alain LaederachDepartment of Biology, The University of North Carolina, Chapel Hill, North Carolina 27599.ORCID 0000-0002-5088-9907
Samuel A McLeanInstitute for Trauma Recovery.ORCID 0000-0001-9482-3582
University of North Carolina at Chapel Hill · USDetroit Receiving Hospital · USEinstein Medical Center Philadelphia · USHenry Ford Hospital · USMedStar Washington Hospital Center · USMercy Health System · USRoyal College of Emergency Medicine · GBSaratov Research Institute of Traumatology and Orthopedics · RUUniversity of Alabama · USUniversity of Florida · US
Funding
Applying Biopsychosocial Model to Post-MVC Pain Development in African AmericansR01AR060852 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCLEAN, SAMUEL A. · 2011 to 2015
$3.6MStructural and functional consequences of disease SNPs on the transcriptomeR01GM101237 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAEDERACH, ALAIN T · 2012 to 2020
$2.5MPredicting the causative SNPs in LD blocks by allele-specific structural analysisR01HG008133 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAEDERACH, ALAIN T, WEEKS, KEVIN M · 2015 to 2017
$2.4MNHGRI NIH HHS R01 HG008133NIAMS NIH HHS R01 AR060852NIGMS NIH HHS R01 GM101237
Abstract
Previous studies have shown that common variants of the gene coding for FK506-binding protein 51 (
Indexed as
3' Untranslated RegionsAdultAllelesBlack or African AmericanChronic PainFemaleGenotypeHumansMaleMicroRNAsMusculoskeletal PainPolymorphism, Single NucleotideProtein BindingProtein Structure, SecondaryReceptors, GlucocorticoidRNA, Messenger3' Untranslated RegionsMicroRNAsMIRN320 microRNA, humanNR3C1 protein, humanReceptors, GlucocorticoidRNA, MessengerTacrolimus Binding Protein 5Tacrolimus Binding Proteinschronic painFKBP5functional geneticsmicroRNApost-traumatic stressRNA structure
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.