Evidence map›Paper›PMID 30150362›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Regulators of G-Protein Signaling (RGS) Proteins Promote Receptor Coupling to G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels.

Kylie B McPherson, Emily R Leff, Ming-Hua Li, Claire Meurice, Sherrica Tai, John R Traynor, Susan L Ingram

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. GABAMedComm · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Mechanisms and Regulation of Neuronal GABACurrent topics in behavioral neurosciences · 2022
    Review
  10. Review
  11. Article
  12. Functional Characterization of the Obesity-Linked Variant of the βInternational journal of molecular sciences · 2021
    Article
  13. Review
  14. Review
  15. GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Article
  17. Review
  18. Article
  19. Infection by the parasitic helminthProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Kylie B McPhersonDepartment of Neurological Surgery, Oregon Health & Science University, Portland, Oregon 97239.
Emily R LeffDepartment of Neurological Surgery, Oregon Health & Science University, Portland, Oregon 97239.
Ming-Hua LiDepartment of Neurological Surgery, Oregon Health & Science University, Portland, Oregon 97239.ORCID 0000-0001-7924-3424
Claire MeuriceDepartment of Pharmacology, and.
Sherrica TaiDepartment of Pharmacology, and.
John R TraynorDepartment of Pharmacology, and.
Susan L IngramDepartment of Neurological Surgery, Oregon Health & Science University, Portland, Oregon 97239, Ingrams@ohsu.edu.ORCID 0000-0003-1371-8532
Oregon Health & Science University · USUniversity of Michigan · USInstitute of Pharmacology · CZ

Funding

Travel Grant PA-18-591T32NS007466 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Kelly R Monk, Kevin Wright · 1999 to 2026
$7.0M
Regulator of G protein signaling proteins differentially control opioid analgesiaR01DA035316 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TRAYNOR, JOHN R. · 2014 to 2018
$2.7M
NIDA NIH HHS R01 DA035316NINDS NIH HHS T32 NS007466
6 · The paper itself

Abstract

Regulators of G-protein signaling (RGS) proteins negatively modulate presynaptic μ-opioid receptor inhibition of GABA release in the ventrolateral periaqueductal gray (vlPAG). Paradoxically, we find that G-protein-coupled receptor (GPCR) activation of G-protein-gated inwardly rectifying K

Indexed as

AnalgesicsAnimalsBaclofenFemaleGABA-B Receptor AgonistsG Protein-Coupled Inwardly-Rectifying Potassium ChannelsLocomotionMaleMice, TransgenicNeuronsPeriaqueductal GrayReceptors, GABA-BReceptors, Opioid, muRGS ProteinsAnalgesicsBaclofenGABA-B Receptor AgonistsG Protein-Coupled Inwardly-Rectifying Potassium ChannelsReceptors, GABA-BReceptors, Opioid, muRGS Proteinsanalgesiadescending pain pathwayGABAB receptoropioidsperiqueductal grayRGS proteins

Identifiers

PMID30150362
PMCPMC6181307
OpenAlexW2889439443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.