ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Thalamus Controls Development and Expression of Arousal States in Visual Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Decoding Brain Development and Function Through GABAergic Inhibitory Neurons.The European journal of neuroscience · 2026Review
- Motor cortex activity during sleep and wake movements sharpens across development but continues to lag the red nucleus.Scientific reports · 2026Article
- Sensory modality-specific wiring of thalamocortical circuits.Nature reviews. Neuroscience · 2025Review
- Striatal output regulates the postnatal maturation of cortical circuits.Cell reports · 2025Article
- Noradrenaline Regulation of Brain-Body Communication.Advances in experimental medicine and biology · 2025Review
- More Than a Small Brain: The Importance of Studying Neural Function during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Experience Dependence of Alpha Rhythms and Neural Dynamics in the Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Disruption of Cholinergic Retinal Waves Alters Visual Cortex Development and Function.bioRxiv : the preprint server for biology · 2024Article
- Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder.Journal of Zhejiang University. Science. B · 2024Article
- Generation and propagation of bursts of activity in the developing basal ganglia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- Building thalamic neuronal networks during mouse development.Frontiers in neural circuits · 2023Review
- Sleep, plasticity, and sensory neurodevelopment.Neuron · 2022Review
- Robust effects of corticothalamic feedback and behavioral state on movie responses in mouse dLGN.eLife · 2022Article
- Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations.Neuron · 2022Article
- Movements during sleep reveal the developmental emergence of a cerebellar-dependent internal model in motor thalamus.Current biology : CB · 2021Article
- Review
- Network Dynamics in the Developing Piriform Cortex of Unanesthetized Rats.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Polynomial, piecewise-Linear, Step (PLS): A Simple, Scalable, and Efficient Framework for Modeling Neurons.Frontiers in neuroinformatics · 2021Article
- Transient cortical circuits match spontaneous and sensory-driven activity during development.Science (New York, N.Y.) · 2020Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Two major checkpoints of development in cerebral cortex are the acquisition of continuous spontaneous activity and the modulation of this activity by behavioral state. Despite the critical importance of these functions, the circuit mechanisms of their development remain unknown. Here we use the rodent visual system as a model to test the hypothesis that the locus of circuit change responsible for the developmental acquisition of continuity and state dependence measured in sensory cortex is relay thalamus, rather than the local cortical circuitry or the interconnectivity of the two structures. We conducted simultaneous recordings in the dorsal lateral geniculate nucleus (dLGN) and primary visual cortex (VC) of awake, head-fixed male and female rats using linear multielectrode arrays throughout early development. We find that activity in dLGN becomes continuous and positively correlated with movement (a measure of state dependence) on P13, the same day as VC, and that these properties are not dependent on VC activity. By contrast, silencing dLGN after P13 causes activity in VC to become discontinuous and movement to suppress, rather than augment, cortical firing, effectively reversing development. Thalamic bursting, a core characteristic of non-aroused states, emerged later, on P16, suggesting these processes are developmentally independent. Together our results indicate that cellular or circuit changes in relay thalamus are critical drivers for the maturation of background activity, which occurs around term in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.